1,12,23-tris(benzyloxy)-1,6,12,17,23,28-hexaazacyclotritriacontane-2,5,13,16,24,27-hexone

Base Information

Chemical Name:1,12,23-tris(benzyloxy)-1,6,12,17,23,28-hexaazacyclotritriacontane-2,5,13,16,24,27-hexone
CAS No.:130946-44-0
Molecular Formula:C₄₈H₆₆N₆O₉
Molecular Weight:871.087
Hs Code.:

Synonyms:1,12,23-tris(benzyloxy)-1,6,12,17,23,28-hexaazacyclotritriacontane-2,5,13,16,24,27-hexone

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Chemical Property of 1,12,23-tris(benzyloxy)-1,6,12,17,23,28-hexaazacyclotritriacontane-2,5,13,16,24,27-hexone

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of 1,12,23-tris(benzyloxy)-1,6,12,17,23,28-hexaazacyclotritriacontane-2,5,13,16,24,27-hexone

There total 16 articles about 1,12,23-tris(benzyloxy)-1,6,12,17,23,28-hexaazacyclotritriacontane-2,5,13,16,24,27-hexone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 130946-43-9
5,16,27-tris(benzyloxy)-32-amino-4,12,15,23,26-pentaoxo-5,11,16,22,27-pentaazadotriacontanoic acid

: 130946-44-0
1,12,23-tris(benzyloxy)-1,6,12,17,23,28-hexaazacyclotritriacontane-2,5,13,16,24,27-hexone

Guidance literature:: With diphenylphosphoranyl azide; In N,N-dimethyl-formamide; at -1 - 8 ℃; for 96h;
DOI:10.1016/S0040-4020(01)87913-8

Reference yield:

: 129245-21-2
O-benzyl-N-(5-aminopentyl)-N-(tert-butoxycarbonyl)hydroxylamine

: 130946-44-0
1,12,23-tris(benzyloxy)-1,6,12,17,23,28-hexaazacyclotritriacontane-2,5,13,16,24,27-hexone

Guidance literature:: Multi-step reaction with 5 steps

1: 44 percent / DCC, DMAP / CH₂Cl₂ / 96 h / 0 deg C to r.t.

2: 2.46 g / TFA / CH₂Cl₂ / 1) 3 min, 0 deg C, 2) 17 min, without cooling

3: 78 percent / pyridine / 1.87 h / 101 °C

4: 21 percent / H₂, NH₃, conc.NH₄OH / Raney nickel W-2 / methanol / 3 h / 0 °C / 2947.7 - 3102.9 Torr

5: 54 percent / diphenylphosphoryl azide / dimethylformamide / 96 h / -1 - 8 °C

With pyridine; dmap; ammonium hydroxide; diphenylphosphoranyl azide; hydrogen; dicyclohexyl-carbodiimide; trifluoroacetic acid; Raney nickel W-2; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)87913-8

Reference yield:

: 129245-24-5
5,16-bis(benzyloxy)-20-cyano-4,12,15-trioxo-5,11,16-triazaeicosanoic acid

: 130946-44-0
1,12,23-tris(benzyloxy)-1,6,12,17,23,28-hexaazacyclotritriacontane-2,5,13,16,24,27-hexone

Guidance literature:: Multi-step reaction with 5 steps

1: 44 percent / DCC, DMAP / CH₂Cl₂ / 96 h / 0 deg C to r.t.

2: 2.46 g / TFA / CH₂Cl₂ / 1) 3 min, 0 deg C, 2) 17 min, without cooling

3: 78 percent / pyridine / 1.87 h / 101 °C

4: 21 percent / H₂, NH₃, conc.NH₄OH / Raney nickel W-2 / methanol / 3 h / 0 °C / 2947.7 - 3102.9 Torr

5: 54 percent / diphenylphosphoryl azide / dimethylformamide / 96 h / -1 - 8 °C

With pyridine; dmap; ammonium hydroxide; diphenylphosphoranyl azide; hydrogen; dicyclohexyl-carbodiimide; trifluoroacetic acid; Raney nickel W-2; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)87913-8