C₁₃H₉F₄NO₂S

Base Information

• Chemical Name: C₁₃H₉F₄NO₂S
• CAS No.: 1415115-12-6
• Molecular Formula: C₁₃H₉F₄NO₂S
• Molecular Weight: 319.28
• Mol file: 1415115-12-6.mol

Synonyms:C₁₃H₉F₄NO₂S

Chemical Property of C₁₃H₉F₄NO₂S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₁₃H₉F₄NO₂S

There total 3 articles about C₁₃H₉F₄NO₂S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4-Iodobenzotrifluoride (455-13-0) + 2-pyridyl fluoroiodomethyl sulfone (1415115-02-4) → C13H9F4NO2S (1415115-12-6)

Guidance literature:

2-pyridyl fluoroiodomethyl sulfone; With diethylzinc; In hexane; N,N-dimethyl-formamide; at -30 - -25 ℃; for 0.0833333h; Inert atmosphere;

With copper(l) iodide; In hexane; N,N-dimethyl-formamide; at -15 ℃; for 0.25h; Inert atmosphere;

4-Iodobenzotrifluoride; In hexane; N,N-dimethyl-formamide; at 20 ℃; for 8h; Inert atmosphere;

DOI:10.1021/ol3029737

Reference yield: 73.0%

4-Iodobenzotrifluoride (455-13-0) + 2-fluoro-1-(4-methoxyphenyl)-2-(pyridin-2-ylsulfonyl)ethanone (1365765-67-8) → C13H9F4NO2S (1415115-12-6)

Guidance literature:

4-Iodobenzotrifluoride; 2-fluoro-1-(4-methoxyphenyl)-2-(pyridin-2-ylsulfonyl)ethanone; With copper(I) thiophene-2-carboxylate; sodium hydrogencarbonate; In dimethyl sulfoxide; at 80 ℃; for 20h;

With methanol; In dimethyl sulfoxide; at 80 ℃; for 1h;

DOI:10.1021/cs4000574

Reference yield:

2-((fluoromethyl)sulfonyl)pyridine (1365765-53-2) → C13H9F4NO2S (1415115-12-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium tert-butylate; N-iodo-succinimide / N,N-dimethyl-formamide / 0.5 h / 5 °C / Inert atmosphere

2.1: diethylzinc / N,N-dimethyl-formamide; hexane / 0.08 h / -30 - -25 °C / Inert atmosphere

2.2: 0.25 h / -15 °C / Inert atmosphere

2.3: 8 h / 20 °C / Inert atmosphere

With N-iodo-succinimide; potassium tert-butylate; diethylzinc; In hexane; N,N-dimethyl-formamide;

DOI:10.1021/ol3029737

upstream raw materials:

4-Iodobenzotrifluoride

2-pyridyl fluoroiodomethyl sulfone

2-((fluoromethyl)sulfonyl)pyridine

2-fluoro-1-(4-methoxyphenyl)-2-(pyridin-2-ylsulfonyl)ethanone