Technology Process of C15H18N2
There total 7 articles about C15H18N2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C16H23NO2;
With
hydrogenchloride; water;
In
isopropyl alcohol;
for 48h;
With
1,8-diazabicyclo[5.4.0]undec-7-ene;
In
isopropyl alcohol;
at 20 ℃;
for 20h;
sodium cyanide;
In
isopropyl alcohol;
for 80h;
Overall yield = 74 %;
- Guidance literature:
-
C19H27NO3;
With
trifluoroacetic acid;
In
dichloromethane;
for 1h;
trimethylsilyl cyanide;
In
acetonitrile;
for 3h;
Overall yield = 904.9 mg;
DOI:10.1002/ejoc.201403069
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium bromide; sodium hydrogencarbonate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite / chloroform; water / 4.67 h / 2 - 10 °C
1.2: 12 h / 40 - 45 °C
2.1: acetic acid; (S)-2-(diphenyltrimethylsilyloxymethyl)proline / water; methanol / 25 h
3.1: toluene-4-sulfonic acid / toluene / 2 h / Reflux; Dean-Stark
4.1: hydrogen; 20% palladium hydroxide-activated charcoal / methanol / 2.5 h / 27 °C / 3750.38 Torr
5.1: toluene / 2 h / 120 °C / Dean-Stark
5.2: 2 h / 20 °C / Cooling with ice
6.1: water; hydrogenchloride / isopropyl alcohol / 48 h
6.2: 20 h / 20 °C
6.3: 80 h
With
hydrogenchloride; sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; 20% palladium hydroxide-activated charcoal; (S)-2-(diphenyltrimethylsilyloxymethyl)proline; water; hydrogen; sodium hydrogencarbonate; toluene-4-sulfonic acid; acetic acid; potassium bromide;
In
methanol; chloroform; water; isopropyl alcohol; toluene;
