2-[1-(3-chloropyridine-2-yl)-3-bromo-1H-pyrazole-5-yl]-6-iodo-8-methyl-4H-3,1-benzoxazine-4-one

Base Information

• Chemical Name: 2-[1-(3-chloropyridine-2-yl)-3-bromo-1H-pyrazole-5-yl]-6-iodo-8-methyl-4H-3,1-benzoxazine-4-one
• CAS No.: 736995-63-4
• Molecular Formula: C₁₇H₉BrClIN₄O₂
• Molecular Weight: 543.546
• Mol file: 736995-63-4.mol

Synonyms:2-[1-(3-chloropyridine-2-yl)-3-bromo-1H-pyrazole-5-yl]-6-iodo-8-methyl-4H-3,1-benzoxazine-4-one

Chemical Property of 2-[1-(3-chloropyridine-2-yl)-3-bromo-1H-pyrazole-5-yl]-6-iodo-8-methyl-4H-3,1-benzoxazine-4-one

Chemical Property:

Purity/Quality:

95%-98% ^*data from raw suppliers

2-[5-Bromo-2-(3-chloro-pyridin-2-yl)-2H-pyrazol-3-yl]-6-iodo-8-methyl-benzo[d][1,3]oxazin-4-one 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[1-(3-chloropyridine-2-yl)-3-bromo-1H-pyrazole-5-yl]-6-iodo-8-methyl-4H-3,1-benzoxazine-4-one

There total 2 articles about 2-[1-(3-chloropyridine-2-yl)-3-bromo-1H-pyrazole-5-yl]-6-iodo-8-methyl-4H-3,1-benzoxazine-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.9%

3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic acid (500011-86-9) + 2-amino-5-iodo-3-methylbenzoic acid (108857-24-5) → 2-[1-(3-chloropyridine-2-yl)-3-bromo-1H-pyrazole-5-yl]-6-iodo-8-methyl-4H-3,1-benzoxazine-4-one (736995-63-4)

Guidance literature:

With methanesulfonyl chloride; In acetonitrile; at -8 - 15 ℃; for 3.5h;

Reference yield:

3-methylantranilic acid (4389-45-1) → 2-[1-(3-chloropyridine-2-yl)-3-bromo-1H-pyrazole-5-yl]-6-iodo-8-methyl-4H-3,1-benzoxazine-4-one (736995-63-4)

Guidance literature:

Multi-step reaction with 2 steps

1: iodine; dipotassium peroxodisulfate / tetrachloromethane / 6 h / 77 °C

2: methanesulfonyl chloride; triethylamine / tetrahydrofuran / 3 h / -8 - 15 °C

With dipotassium peroxodisulfate; iodine; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; tetrachloromethane;

Reference yield: 95.5%

2-[1-(3-chloropyridine-2-yl)-3-bromo-1H-pyrazole-5-yl]-6-iodo-8-methyl-4H-3,1-benzoxazine-4-one (736995-63-4) + tert-butylamine (75-64-9) → 1-(3-chloropyridine-2-yl)-3-bromo-N-(2-methyl-4-iodo-6-tert-butylaminocarbonyl)phenyl-1 H-pyrazole-5-formamide

Guidance literature:

In tetrahydrofuran; at 25 - 27 ℃; for 2h;

upstream raw materials:

3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic acid

2-amino-5-iodo-3-methylbenzoic acid

3-methylantranilic acid