1-(4-bromo-5-(1-ethyl-7-(2-methoxyethylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea methanesulfonate

Base Information

• Chemical Name: 1-(4-bromo-5-(1-ethyl-7-(2-methoxyethylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea methanesulfonate
• CAS No.: 1442473-01-9
• Molecular Formula: CH₄O₃S*C₂₆H₂₅BrFN₅O₃
• Molecular Weight: 650.526
• Mol file: 1442473-01-9.mol

Synonyms:1-(4-bromo-5-(1-ethyl-7-(2-methoxyethylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea methanesulfonate

Chemical Property of 1-(4-bromo-5-(1-ethyl-7-(2-methoxyethylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-bromo-5-(1-ethyl-7-(2-methoxyethylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea methanesulfonate

There total 13 articles about 1-(4-bromo-5-(1-ethyl-7-(2-methoxyethylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-bromo-5-(1-ethyl-7-(2-methoxyethylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea (1442472-99-2) → 1-(4-bromo-5-(1-ethyl-7-(2-methoxyethylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea methanesulfonate (1442473-01-9)

Guidance literature:

With methanesulfonic acid; In acetonitrile; at 20 ℃; for 0.5h;

Reference yield:

3-(5-amino-2-bromo-4-fluorophenyl)-1-ethyl-7-(2-methoxyethylamino)-1,6-naphthyridin-2(1H)-one (1442470-69-0) → 1-(4-bromo-5-(1-ethyl-7-(2-methoxyethylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea methanesulfonate (1442473-01-9)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 2 h / 20 °C

2: methanesulfonic acid / acetonitrile / 0.5 h / 20 °C

With methanesulfonic acid; In dichloromethane; acetonitrile;

Reference yield:

6-chloro-4-ethylamino-nicotinic acid ethyl ester (959162-97-1) → 1-(4-bromo-5-(1-ethyl-7-(2-methoxyethylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea methanesulfonate (1442473-01-9)

Guidance literature:

Multi-step reaction with 6 steps

1: lithium aluminium tetrahydride / water; tetrahydrofuran / 1 h / -50 - 0 °C

2: manganese(IV) oxide / dichloromethane / 20 °C

3: potassium fluoride; aluminum oxide / N,N-dimethyl acetamide / 2 h / Sonication

4: 1-methyl-pyrrolidin-2-one / 4 h / 120 °C

5: dichloromethane / 2 h / 20 °C

6: methanesulfonic acid / acetonitrile / 0.5 h / 20 °C

With manganese(IV) oxide; aluminum oxide; potassium fluoride; lithium aluminium tetrahydride; methanesulfonic acid; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl acetamide; water; acetonitrile;

upstream raw materials:

1-(4-bromo-5-(1-ethyl-7-(2-methoxyethylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea

3-(5-amino-2-bromo-4-fluorophenyl)-1-ethyl-7-(2-methoxyethylamino)-1,6-naphthyridin-2(1H)-one

6-chloro-4-ethylamino-nicotinic acid ethyl ester

(6-chloro-4-(ethylamino)pyridin-3-yl)methanol