ethyl 3,3-bis(N-(3-(thiophen-2-yl)prop-2-ynyl)-4-methylphenylsulfonamido)acrylate

Base Information

Chemical Name:ethyl 3,3-bis(N-(3-(thiophen-2-yl)prop-2-ynyl)-4-methylphenylsulfonamido)acrylate
CAS No.:1609632-89-4
Molecular Formula:C₃₃H₃₀N₂O₆S₄
Molecular Weight:678.875
Hs Code.:

Synonyms:ethyl 3,3-bis(N-(3-(thiophen-2-yl)prop-2-ynyl)-4-methylphenylsulfonamido)acrylate

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Chemical Property of ethyl 3,3-bis(N-(3-(thiophen-2-yl)prop-2-ynyl)-4-methylphenylsulfonamido)acrylate

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Technology Process of ethyl 3,3-bis(N-(3-(thiophen-2-yl)prop-2-ynyl)-4-methylphenylsulfonamido)acrylate

There total 4 articles about ethyl 3,3-bis(N-(3-(thiophen-2-yl)prop-2-ynyl)-4-methylphenylsulfonamido)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1428675-78-8
N-[3-(thiophen-2-yl)prop-2-yn-1-yl]-4-methylbenzenesulfonamide

: 41658-03-1
ethyl 3-bromoprop-2-ynoate

: 1609632-89-4
ethyl 3,3-bis(N-(3-(thiophen-2-yl)prop-2-ynyl)-4-methylphenylsulfonamido)acrylate

Guidance literature:: With potassium phosphate; In toluene; at 70 ℃; for 7h; Schlenk technique; Inert atmosphere;
DOI:10.1021/ol501125r

Reference yield:

: 55022-46-3
4-methyl-N-prop-2-ynylbenzenesulfonamide

: 1609632-89-4
ethyl 3,3-bis(N-(3-(thiophen-2-yl)prop-2-ynyl)-4-methylphenylsulfonamido)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 4 h / 20 °C / Schlenk technique; Inert atmosphere

2: potassium phosphate / toluene / 7 h / 70 °C / Schlenk technique; Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; copper(l) iodide; triethylamine; In tetrahydrofuran; toluene; 1: |Sonogashira Cross-Coupling;
DOI:10.1021/ol501125r

Reference yield:

: 18303-04-3
N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide

: 1609632-89-4
ethyl 3,3-bis(N-(3-(thiophen-2-yl)prop-2-ynyl)-4-methylphenylsulfonamido)acrylate

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / Schlenk technique; Inert atmosphere

2: trifluoroacetic acid / Schlenk technique; Inert atmosphere

3: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 4 h / 20 °C / Schlenk technique; Inert atmosphere

4: potassium phosphate / toluene / 7 h / 70 °C / Schlenk technique; Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; copper(l) iodide; di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; toluene; 1: |Mitsunobu Displacement / 3: |Sonogashira Cross-Coupling;
DOI:10.1021/ol501125r