6-(trideuteriomethyl)-4,4,6-trimethyl-2-(o-nitrophenyl)cyclohex-2-en-1-one

Base Information

Chemical Name:6-(trideuteriomethyl)-4,4,6-trimethyl-2-(o-nitrophenyl)cyclohex-2-en-1-one
CAS No.:620943-78-4
Molecular Formula:C₁₆H₁₉NO₃
Molecular Weight:276.308
Hs Code.:

Synonyms:6-(trideuteriomethyl)-4,4,6-trimethyl-2-(o-nitrophenyl)cyclohex-2-en-1-one

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Chemical Property of 6-(trideuteriomethyl)-4,4,6-trimethyl-2-(o-nitrophenyl)cyclohex-2-en-1-one

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Technology Process of 6-(trideuteriomethyl)-4,4,6-trimethyl-2-(o-nitrophenyl)cyclohex-2-en-1-one

There total 4 articles about 6-(trideuteriomethyl)-4,4,6-trimethyl-2-(o-nitrophenyl)cyclohex-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 5570-19-4
2-nitrophenylboronic acid

: 620943-77-3
2-iodo-6-(trideuteriomethyl)-4,4,6-trimethylcyclohex-2-en-1-one

: 620943-78-4
6-(trideuteriomethyl)-4,4,6-trimethyl-2-(o-nitrophenyl)cyclohex-2-en-1-one

Guidance literature:: With barium dihydroxide; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; johnphos; In tetrahydrofuran; at 35 ℃; for 5h;
DOI:10.1021/ja0372006

Reference yield:

: 1073-13-8
4,4-dimethylcyclohexenone

: 620943-78-4
6-(trideuteriomethyl)-4,4,6-trimethyl-2-(o-nitrophenyl)cyclohex-2-en-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: LHMDS / tetrahydrofuran / 1 h / -78 °C

1.2: 72 percent / tetrahydrofuran / 11 h / -78 - 23 °C

2.1: LHMDS / tetrahydrofuran / 0.17 h / -78 °C

2.2: 82 percent / tetrahydrofuran / 12 h / -78 - 23 °C

3.1: 93 percent / I₂; 4-(dimethylamino)pyridine; pyridine / CCl₄ / 2 h / 49 °C

4.1: 93 percent / Pd₂(dba)3; 2-(di-t-butylphosphino)biphenyl; aq. barium hydroxide / tetrahydrofuran / 5 h / 35 °C

With pyridine; dmap; barium dihydroxide; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; iodine; lithium hexamethyldisilazane; johnphos; In tetrahydrofuran; tetrachloromethane; 4.1: Suzuki coupling;
DOI:10.1021/ja0372006

Reference yield:

: 13395-73-8
4,4,6-trimethylcyclohex-2-en-1-one

: 620943-78-4
6-(trideuteriomethyl)-4,4,6-trimethyl-2-(o-nitrophenyl)cyclohex-2-en-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: LHMDS / tetrahydrofuran / 0.17 h / -78 °C

1.2: 82 percent / tetrahydrofuran / 12 h / -78 - 23 °C

2.1: 93 percent / I₂; 4-(dimethylamino)pyridine; pyridine / CCl₄ / 2 h / 49 °C

3.1: 93 percent / Pd₂(dba)3; 2-(di-t-butylphosphino)biphenyl; aq. barium hydroxide / tetrahydrofuran / 5 h / 35 °C

With pyridine; dmap; barium dihydroxide; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; iodine; lithium hexamethyldisilazane; johnphos; In tetrahydrofuran; tetrachloromethane; 3.1: Suzuki coupling;
DOI:10.1021/ja0372006