5570-19-4Relevant articles and documents
Synthesis method of 2-nitrophenylboronic acid pinacol ester
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Paragraph 0020; 0029-0043, (2020/04/17)
The invention relates to a synthetic method of 2-nitrophenylboronic acid pinacol ester, and belongs to the field of synthesis of medical intermediates. Nitrobenzene is used as a raw material and reacts with BCl3 or BBr3 under the catalysis of a catalyst B(C6F5)3 for ortho-orientation, pinacol is added, and the 2-nitrophenylboronic acid pinacol ester is generated under the alkaline condition. According to the method, a common reaction raw material is adopted, selective guiding is carried out under mild conditions, high-purity 2-nitrophenylboronic acid pinacol ester can be obtained through recrystallization of a crude product, 2-aminobenzene boronic acid pinacol ester can be obtained through continuous catalytic hydrogenation, and the defects that in a traditional method, raw material is noteasy to obtain, danger is high, and ultralow temperature or precious metal is needed for use are overcome.
A 2 - nitro phenyl boronic acid synthesis method
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Paragraph 0026-0039, (2017/08/25)
The invention provides a synthetic method of 2-nitro phenyl boric acid. The synthetic method of 2-nitro phenyl boric acid comprises the step of carrying out reaction on phenyl boric acid and nitric acid in presence of an organic solvent and a catalyst. The synthetic method of 2-nitro phenyl boric acid has the advantages that price of recycled materials is low, reaction selectivity is high, isomers in the obtained 2-nitro phenyl boric acid are less, and product purity is high.
A compound with anti-tumor activity of the multitarget kinase inhibitor and its preparation method
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Paragraph 0061-0062, (2017/04/14)
The invention relates to the technical field of medicine, and relates to a type of compounds with antitumor activities, and a preparation method and an application thereof. The compounds have a structural general formula represented below. R1 is alkyl group, heterocyclic group, substituted phenyl group, substituted alicyclic group, or aliphatic heterocyclic group, wherein the substituent is 2,3-ethylenedioxy, 3,4-ethylenedioxy, 2,3-methylenedioxy, or 3,4-methylenedioxy; or all-site-substituted hydrogen, alkyl, alkoxy, halogen, amino, hydroxyl, trifluoromethyl, formate, and the like. R2 is heterocyclic group or substituted phenyl group, wherein the phenyl substituent is 2,3-ethylenedioxy, 3,4-ethylenedioxy, 2,3-methylenedioxy, or 3,4-methylenedioxy; or all-site-substituted hydrogen, alkyl, alkoxy, halogen, amino, hydroxyl, trifluoromethyl, formate, and the like. The compounds provided by the invention have substantial tumor cytotoxic effect and broad-spectrum kinase inhibitory activity, and can be used in preparing antitumor medicines.