4-(N-boc-aminomethyl)-2,6-dichlorobenzenamine

Base Information

• Chemical Name: 4-(N-boc-aminomethyl)-2,6-dichlorobenzenamine
• CAS No.: 917388-81-9
• Molecular Formula: C₁₂H₁₆Cl₂N₂O₂
• Molecular Weight: 291.177
• Mol file: 917388-81-9.mol

Synonyms:4-(N-boc-aminomethyl)-2,6-dichlorobenzenamine

Chemical Property of 4-(N-boc-aminomethyl)-2,6-dichlorobenzenamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(N-boc-aminomethyl)-2,6-dichlorobenzenamine

There total 2 articles about 4-(N-boc-aminomethyl)-2,6-dichlorobenzenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.2%

4-(aminomethyl)-2,6-dichloroaniline (164648-75-3) + di-tert-butyl dicarbonate (24424-99-5) → 4-(N-boc-aminomethyl)-2,6-dichlorobenzenamine (917388-81-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

Reference yield:

4-amino-3,5-dichlorobenzonitrile (78473-00-4) → 4-(N-boc-aminomethyl)-2,6-dichlorobenzenamine (917388-81-9)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 20 °C

2: tetrahydrofuran / 3 h / 20 °C

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1039/d0sc02745f

Reference yield: 43.0%

4-(N-boc-aminomethyl)-2,6-dichlorobenzenamine (917388-81-9) → C24H28Cl4N4O4

Guidance literature:

With N-chloro-succinimide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at -78 ℃; for 0.166667h;

DOI:10.1039/d0sc02745f

upstream raw materials:

4-(aminomethyl)-2,6-dichloroaniline

di-tert-butyl dicarbonate

4-amino-3,5-dichlorobenzonitrile

Downstream raw materials:

N-(4-(N-boc-aminomethyl)-2,6-dichlorophenyl)-2-bromoacetamide

Refernces

• 1、 -. "Oxime-Containing Acyl Guanidines as Beta-Secretase Inhibitors". Page/Page column 8. . Retrieved 2010/11/28.
• 2、 -. "Aminoacetamide acyl guanidines as beta-secretase inhibitors". Page/Page column 38. . Retrieved 2008/06/13.