164648-75-3Relevant academic research and scientific papers
Reversible photo-control over transmembrane anion transport using visible-light responsive supramolecular carriers
Kerckhoffs, Aidan,Langton, Matthew J.
, p. 6325 - 6331 (2020/08/24)
Ion transport across lipid bilayer membranes in biology is controlled by membrane proteins, which in turn are regulated in response to chemical-, physical- and photo-stimuli. The design of synthetic supramolecular ion transporters able to be precisely con
Acyl guanidine inhibitors of β-secretase (bACE-1): Optimization of a micromolar hit to a nanomolar lead via iterative solid- and solution-phase library synthesis
Gerritz, Samuel W.,Zhai, Weixu,Shi, Shuhao,Zhu, Shirong,Toyn, Jeremy H.,Meredith, Jere E.,Iben, Lawrence G.,Burton, Catherine R.,Albright, Charles F.,Good, Andrew C.,Cook, Lynda S.,Padmanabha, Ramesh,Lentz, Kimberley A.,Sofia, Michael J.,MacOr, John E.,Thompson, Lorin A.,Tebben, Andrew J.,Muckelbauer, Jodi K.,Camac, Daniel M.,Metzler, William,Poss, Michael A.
supporting information, p. 9208 - 9223,16 (2020/10/15)
This report describes the discovery and optimization of a BACE-1 inhibitor series containing an unusual acyl guanidine chemotype that was originally synthesized as part of a 6041-membered solid-phase library. The synthesis of multiple follow-up solid- and
Macrocyclic Acyl Guanidines as Beta-Secretase Inhibitors
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Page/Page column 6, (2008/12/04)
There is provided a series of heterocyclic-containing macrocyclic acyl guanidines of Formula (I) or a stereoisomer; or a nontoxic pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5,
Indole acetic acid acyl guanidines as beta-secretase inhibitors
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Page/Page column 12, (2008/06/13)
There is provided a series of substituted acyl guanidines of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, and
Oxime-Containing Acyl Guanidines as Beta-Secretase Inhibitors
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Page/Page column 6-7, (2010/11/28)
There is provided a series of substituted oxime-containing acyl guanidines of Formula (I) or a stereoisomer; or a nontoxic pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6
N-Aryl Pyrrolidine Derivatives as Beta-Secretase Inhibitors
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Page/Page column 8, (2010/11/28)
There is provided a series of substituted N-aryl pyrrolidine derivatives of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R5′, R6, R7, and p as defined herein, their pharmaceutical compositions and methods of use. These compounds inhibit the processing of amyloid precursor protein (APP) by β-secretase and, more specifically, inhibit the production of Aβ-peptide. The present disclosure is directed to compounds useful in the treatment of neurological disorders related to β-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.
Aminoacetamide acyl guanidines as beta-secretase inhibitors
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Page/Page column 19-20, (2008/06/13)
There is provided a series of substituted acyl guanidines of Formula (Ik) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R2, R3, R4, R5, R25, R26 and R27 as defined herein, their pharmaceutical compositions and methods of use. These compounds inhibit the processing of amyloid precursor protein (APP) by β-secretase and, more specifically, inhibit the production of Aβ-peptide. The present disclosure is directed to compounds useful in the treatment of neurological disorders related to β-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.
