(2R,3S)-4-cyclohexyl-1-(isopropylsulfonyl)-2-hydroxybutane hydrochloride

Base Information

• Chemical Name: (2R,3S)-4-cyclohexyl-1-(isopropylsulfonyl)-2-hydroxybutane hydrochloride
• CAS No.: 103127-91-9
• Molecular Formula: C₁₃H₂₇NO₃S*ClH
• Molecular Weight: 313.889

Synonyms:(2R,3S)-4-cyclohexyl-1-(isopropylsulfonyl)-2-hydroxybutane hydrochloride

Chemical Property of (2R,3S)-4-cyclohexyl-1-(isopropylsulfonyl)-2-hydroxybutane hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (2R,3S)-4-cyclohexyl-1-(isopropylsulfonyl)-2-hydroxybutane hydrochloride

There total 3 articles about (2R,3S)-4-cyclohexyl-1-(isopropylsulfonyl)-2-hydroxybutane hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,3S)-3-(t-Boc-amino)-4-cyclohexyl-1-(isopropylsulfonyl)-2-hydroxybutane (110206-09-2) → (2R,3S)-4-cyclohexyl-1-(isopropylsulfonyl)-2-hydroxybutane hydrochloride (103127-91-9)

Guidance literature:

With hydrogenchloride; In ethanol; Ambient temperature;

DOI:10.1021/jm00394a035

Reference yield:

(2R,3S)-3-(t-butoxycarbonylamino)-4-cyclohexyl-1,2-epoxybutane (107202-61-9) → (2R,3S)-4-cyclohexyl-1-(isopropylsulfonyl)-2-hydroxybutane hydrochloride (103127-91-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 59 percent / triethylamine / methanol / 2 h / Heating

2: 97 percent / m-chloroperoxybenzoic acid / CH₂Cl₂ / 1 h

3: HCl / ethanol / Ambient temperature

With hydrogenchloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In methanol; ethanol; dichloromethane;

DOI:10.1021/jm00394a035

Reference yield:

(2R,3S)-3-(t-Boc-amino)-4-cyclohexyl-2-hydroxy-1-(isopropylthio)butane (110206-07-0) → (2R,3S)-4-cyclohexyl-1-(isopropylsulfonyl)-2-hydroxybutane hydrochloride (103127-91-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / m-chloroperoxybenzoic acid / CH₂Cl₂ / 1 h

2: HCl / ethanol / Ambient temperature

With hydrogenchloride; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane;

DOI:10.1021/jm00394a035

upstream raw materials:

(2R,3S)-3-(t-Boc-amino)-4-cyclohexyl-1-(isopropylsulfonyl)-2-hydroxybutane

(2R,3S)-3-(t-butoxycarbonylamino)-4-cyclohexyl-1,2-epoxybutane

(2R,3S)-3-(t-Boc-amino)-4-cyclohexyl-2-hydroxy-1-(isopropylthio)butane

Downstream raw materials:

{(S)-1-[(1S,2R)-1-Cyclohexylmethyl-2-hydroxy-3-(propane-2-sulfonyl)-propylcarbamoyl]-3-methyl-butyl}-carbamic acid tert-butyl ester

[(S)-1-[(1S,2R)-1-Cyclohexylmethyl-2-hydroxy-3-(propane-2-sulfonyl)-propylcarbamoyl]-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid tert-butyl ester

N-{(S)-1-[(S)-1-[(1S,2R)-1-Cyclohexylmethyl-2-hydroxy-3-(propane-2-sulfonyl)-propylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-3,3-dimethyl-butyramide

((S)-1-{(S)-5-Amino-1-[(1S,2R)-1-cyclohexylmethyl-2-hydroxy-3-(propane-2-sulfonyl)-propylcarbamoyl]-pentylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester

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