6-chloro-2-(4-chlorophenylamino)-4-methylamino-3-nitropyridine

Base Information

• Chemical Name: 6-chloro-2-(4-chlorophenylamino)-4-methylamino-3-nitropyridine
• CAS No.: 1043893-80-6
• Molecular Formula: C₁₂H₁₀Cl₂N₄O₂
• Molecular Weight: 313.143
• Mol file: 1043893-80-6.mol

Synonyms:6-chloro-2-(4-chlorophenylamino)-4-methylamino-3-nitropyridine

Chemical Property of 6-chloro-2-(4-chlorophenylamino)-4-methylamino-3-nitropyridine

Chemical Property:

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Technology Process of 6-chloro-2-(4-chlorophenylamino)-4-methylamino-3-nitropyridine

There total 1 articles about 6-chloro-2-(4-chlorophenylamino)-4-methylamino-3-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

2,6-dichloro-N-methyl-3-nitro pyridine-4-amine (887147-20-8) + N-(4-chlorophenyl)formamide (2617-79-0) → 6-chloro-2-(4-chlorophenylamino)-4-methylamino-3-nitropyridine (1043893-80-6)

Guidance literature:

N-(4-chlorophenyl)formamide; With sodium hydride; In tetrahydrofuran; for 0.5h;

2,6-dichloro-N-methyl-3-nitro pyridine-4-amine; In tetrahydrofuran; for 72h; Heating / reflux;

Reference yield: 96.0%

3,5-dimethyl-1H-pyrazole (67-51-6) + 6-chloro-2-(4-chlorophenylamino)-4-methylamino-3-nitropyridine (1043893-80-6) → 2-(4-chlorophenylamino)-6-(3,5-dimethylpyrazol-1-yl)-4-methylamino-3-nitropyridine (1043893-81-7)

Guidance literature:

3,5-dimethyl-1H-pyrazole; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.5h;

6-chloro-2-(4-chlorophenylamino)-4-methylamino-3-nitropyridine; In tetrahydrofuran; for 120h; Heating / reflux;

upstream raw materials:

2,6-dichloro-N-methyl-3-nitro pyridine-4-amine

N-(4-chlorophenyl)formamide

Downstream raw materials:

2-(4-chlorophenylamino)-6-(3,5-dimethylpyrazol-1-yl)-4-methylamino-3-nitropyridine