887147-20-8

Basic information

• Product Name: 2,6-dichloro-N-Methyl-3-nitropyridin-4-aMine
• Synonyms: 2,6-dichloro-N-Methyl-3-nitropyridin-4-aMine
• CAS NO: 887147-20-8
• Molecular Formula: C₆H₅Cl₂N₃O₂
• Molecular Weight: 222.0288
• Mol File: 887147-20-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 383.7±42.0 °C(Predicted)
• Appearance: /
• Density: 1.610±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: -1.95±0.10(Predicted)
• CAS DataBase Reference: 2,6-dichloro-N-Methyl-3-nitropyridin-4-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-dichloro-N-Methyl-3-nitropyridin-4-aMine(887147-20-8)
• EPA Substance Registry System: 2,6-dichloro-N-Methyl-3-nitropyridin-4-aMine(887147-20-8)

Safety Data

• Hazardous Substances Data: 887147-20-8(Hazardous Substances Data)

Usage

General Description

2,6-dichloro-N-Methyl-3-nitropyridin-4-aMine is a chemical compound with the molecular formula C7H6Cl2N3O2. It is a yellow crystalline solid with a molecular weight of 222.05 g/mol. 2,6-dichloro-N-Methyl-3-nitropyridin-4-aMine is commonly used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It is a known mutagen and has been used in laboratory research to induce mutations in bacterial DNA for studying the effects of genetic modification. It is important to handle this chemical with caution, as it is known to be harmful if swallowed, inhaled, or in contact with the skin, and can cause irritation to the respiratory system and skin. Proper safety measures should be taken when handling this compound to minimize the risk of exposure and harm.

Upstream product

• 175461-33-3 2,6-dichloro-N-methylpyridine-4-amine 
• 2897-43-0 2,6-dichloro-3-nitropyridin-4-amine 
• 74-88-4 methyl iodide 
• 2587-00-0 2,6-dichloropyridine N-oxide 
• 2402-78-0 2,6-dichloropyridine 
• 1569084-56-5 tert-butyl 2,6-dichloropyridin-4-yl(methyl)carbamate 
• 501907-61-5 tert-butyl (2,6-dichloropyridin-4-yl)carbamate 
• 2587-02-2 2,6-dichloro-[4]pyridylamine 
• 16063-69-7 2,4,6-trichloropyridine 
• 914942-85-1 2,6-dichloro-N-methyl-N-nitro pyridine-4-amine 

Downstream Products

• 914944-26-6 3-((4-tert-butyloxycarbonyl(methyl)amino)-1-methyl-6-(2,2,2-trifluoroacetamido)-1H-imidazo[4,5-c]pyridin-7-yl)ethynyl-5-fluorobenzoic acid methyl ester 
• 914943-46-7 N-[[3-[1,5-dihydro-1-methyl-4-(methyl-t-butyloxycarbonylamino)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl]phenyl]methyl]trimethylacetamide 
• 914943-90-1 3-[6-amino-4-(tert-butoxycarbonyl-methyl-amino)-1-methyl-1H-imidazo[4,5-d]pyridin-7-ylethynyl]-benzoic acid tert-butyl ester 
• 914944-25-5 3-((6-amino-4-(tert-butyloxycarbonyl(methyl)amino)-1-methyl-1H-imidazo[4,5-c]pyridine-7-yl)ethynyl)-5-fluorobenzoic acid methyl ester 
• 914944-30-2 3-[1,6-dihydro-1-methyl-4-((methyl)tert-butoxycarbonylamino)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl]-5-fluoro-benzoic acid 
• 914942-98-6 N-[[3-[1,6-dihydro-1-methyl-4-(methyl-t-butyloxycarbonylamino)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl]phenyl]methyl]acetamide 
• 914944-27-7 3-[1,6-dihydro-1-methyl-4-((methyl)tert-butoxycarbonylamino)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl]-5-fluoro-benzoic acid methyl ester 
• 914944-37-9 tert-butyl 6-amino-7-(2-(4-cyanophenyl)ethynyl)-1-methyl-1H-imidazo[4,5-c]pyridin-4-yl(methyl)carbamate 
• 914942-92-0 tert-butyl 6-amino-7-(2-(3-cyanophenyl)ethynyl)-1-methyl-1H-imidazo[4,5-c]pyridin-4-yl(methyl)carbamate 
• 914943-95-6 tert-butyl 6-amino-1-methyl-7-(2-(3-bromophenyl)ethynyl)-1H-imidazo[4,5-d]pyridin-4-yl(methyl)carbamate 
• 914944-36-8 7-[4-(aminomethyl)phenyl]-1,5-dihydro-N,1-dimethyl-imidazo[4,5-c]pyrrolo[2,3-b]pyridin-4-(t-butyloxycarbonylamine) 
• 914942-96-4 7-[3-(aminomethyl)phenyl]-1,6-dihydro-N,1-dimethyl-imidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-(t-butyloxycarbonylamine) 
• 914944-38-0 4-[1,5-dihydro-1-methyl-4-(N-tert-butyloxycarbonyl-N-methylamino)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl]benzonitrile 
• 914942-93-1 3-[1,6-dihydro-1-methyl-4-(N-tert-butyloxycarbonyl-N-methylamino)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl]benzonitrile 

Relevant articles and documents

Bicyclic compound, preparation method and application thereof

The invention belongs to the field of medicines, and particularly relates to a compound represented by a formula I, a stereoisomer, a tautomer or a mixture of the stereoisomer and the tautomer of thecompound, a pharmaceutically acceptable salt, eutectic, polymorph or solvate of the compound, or a stable isotope derivative, metabolite or prodrug of the compound.

NOVEL TRIAZOLOPYRIMIDINONE OR TRIAZOLOPYRIDINONE DERIVATIVES, AND USE THEREOF

The present invention relates to a novel triazolopyrimidinone or triazolopyridinone derivative, a tautomer thereof, a stereoisomer thereof and their mixture, or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition for preventing or treating a tankyrase-related disease, which contains the same as an active ingredient.

ALKYNYL ALCOHOLS AND METHODS OF USE

The invention relates to compounds of Formula (0): wherein A1-A8, R4 and R5 each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.