<2-(ortho-acetoxy-phenyl)-2-oxo>ethyl dibenzylphosphate

Base Information

• Chemical Name: <2-(ortho-acetoxy-phenyl)-2-oxo>ethyl dibenzylphosphate
• CAS No.: 154470-10-7
• Molecular Formula: C₂₄H₂₃O₇P
• Molecular Weight: 454.416
• Mol file: 154470-10-7.mol

Synonyms:<2-(ortho-acetoxy-phenyl)-2-oxo>ethyl dibenzylphosphate

Chemical Property of <2-(ortho-acetoxy-phenyl)-2-oxo>ethyl dibenzylphosphate

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <2-(ortho-acetoxy-phenyl)-2-oxo>ethyl dibenzylphosphate

There total 4 articles about <2-(ortho-acetoxy-phenyl)-2-oxo>ethyl dibenzylphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

phosphoric acid dibenzyl ester (1623-08-1) + ortho-acetoxy-ω-diazoketophenone (41997-32-4) → <2-(ortho-acetoxy-phenyl)-2-oxo>ethyl dibenzylphosphate (154470-10-7)

Guidance literature:

In benzene; at 80 ℃; for 7h;

DOI:10.1016/S0968-0896(96)00221-0

Reference yield:

aspirin (50-78-2,98201-60-6) → <2-(ortho-acetoxy-phenyl)-2-oxo>ethyl dibenzylphosphate (154470-10-7)

Guidance literature:

Multi-step reaction with 3 steps

1: oxalyl chloride / CH₂Cl₂ / 2 h / Heating

2: diethyl ether / 1 h / -50 - 20 °C

3: 70 percent / benzene / 65 °C

With oxalyl dichloride; In diethyl ether; dichloromethane; benzene;

DOI:10.1080/00397919408012621

Reference yield:

O-acetylsalicyloyl chloride (5538-51-2) → <2-(ortho-acetoxy-phenyl)-2-oxo>ethyl dibenzylphosphate (154470-10-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / diethyl ether / 2 h / Ambient temperature

2: 90 percent / benzene / 7 h / 80 °C

In diethyl ether; benzene;

DOI:10.1016/S0968-0896(96)00221-0

upstream raw materials:

phosphoric acid dibenzyl ester

ortho-acetoxy-ω-diazoketophenone

O-acetylsalicyloyl chloride

aspirin

Downstream raw materials:

Phosphoric acid dibenzyl ester 2-(2-hydroxy-phenyl)-2,2-dimethoxy-ethyl ester