tert-butyl 4-(7-(2-fluoro-5-(3-(3-(trifluoromethyl)phenyl)ureido)benzoyl)quinoxalin-2-yl)piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(7-(2-fluoro-5-(3-(3-(trifluoromethyl)phenyl)ureido)benzoyl)quinoxalin-2-yl)piperazine-1-carboxylate
CAS No.:1427632-56-1
Molecular Formula:C₃₂H₃₀F₄N₆O₄
Molecular Weight:638.622
Hs Code.:

Synonyms:tert-butyl 4-(7-(2-fluoro-5-(3-(3-(trifluoromethyl)phenyl)ureido)benzoyl)quinoxalin-2-yl)piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-(7-(2-fluoro-5-(3-(3-(trifluoromethyl)phenyl)ureido)benzoyl)quinoxalin-2-yl)piperazine-1-carboxylate

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Technology Process of tert-butyl 4-(7-(2-fluoro-5-(3-(3-(trifluoromethyl)phenyl)ureido)benzoyl)quinoxalin-2-yl)piperazine-1-carboxylate

There total 15 articles about tert-butyl 4-(7-(2-fluoro-5-(3-(3-(trifluoromethyl)phenyl)ureido)benzoyl)quinoxalin-2-yl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.6%

: 1427632-55-0
tertbutyl-4-(7-(5-amino-2-fluorobenzoyl)quinoxalin-2-yl)piperazine-1-carboxylate

: 329-01-1
1-isocyanato-3-trifluoromethyl-benzene

: 1427632-56-1
tert-butyl 4-(7-(2-fluoro-5-(3-(3-(trifluoromethyl)phenyl)ureido)benzoyl)quinoxalin-2-yl)piperazine-1-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 89891-65-6
7-bromo-2-chloroquinoxaline

: 1427632-56-1
tert-butyl 4-(7-(2-fluoro-5-(3-(3-(trifluoromethyl)phenyl)ureido)benzoyl)quinoxalin-2-yl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 13 steps

1.1: potassium carbonate / 2 h / Reflux

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium acetate / N,N-dimethyl-formamide / 90 °C / 22502.3 Torr / Inert atmosphere

3.1: methanol; sodium hydroxide / 1 h / 60 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.17 h

4.2: 20 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

6.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C

6.2: 1 h / -78 °C

7.1: manganese(IV) oxide / dichloromethane / 50 °C

8.1: hydrogenchloride / methanol; water / 0 - 20 °C

9.1: thionyl chloride / 5 h / Reflux

10.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 6 h / 90 °C

11.1: hydrogenchloride; acetic acid / water / 4 h / 110 °C

12.1: triethylamine / tetrahydrofuran / 1 h / 20 °C

13.1: triethylamine / dichloromethane / 1 h / 20 °C

With hydrogenchloride; methanol; manganese(IV) oxide; lithium aluminium tetrahydride; n-butyllithium; thionyl chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium acetate; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1196-57-2
quinoxalin-2⁽¹⁾-one

: 1427632-56-1
tert-butyl 4-(7-(2-fluoro-5-(3-(3-(trifluoromethyl)phenyl)ureido)benzoyl)quinoxalin-2-yl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 15 steps

1.1: bromine; acetic acid / 12 h / 20 °C

2.1: trichlorophosphate / N,N-dimethyl-formamide / 2 h / 120 °C

3.1: potassium carbonate / 2 h / Reflux

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium acetate / N,N-dimethyl-formamide / 90 °C / 22502.3 Torr / Inert atmosphere

5.1: methanol; sodium hydroxide / 1 h / 60 °C

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.17 h

6.2: 20 °C

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

8.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C

8.2: 1 h / -78 °C

9.1: manganese(IV) oxide / dichloromethane / 50 °C

10.1: hydrogenchloride / methanol; water / 0 - 20 °C

11.1: thionyl chloride / 5 h / Reflux

12.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 6 h / 90 °C

13.1: hydrogenchloride; acetic acid / water / 4 h / 110 °C

14.1: triethylamine / tetrahydrofuran / 1 h / 20 °C

15.1: triethylamine / dichloromethane / 1 h / 20 °C

With hydrogenchloride; methanol; manganese(IV) oxide; lithium aluminium tetrahydride; n-butyllithium; thionyl chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bromine; sodium acetate; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;