3-acetyl-5-(4-cyano-phenyl)-2-(5-nitrofuran-2-yl)-2,3-dihydro-1,3,4-oxadiazole

Base Information

Chemical Name:3-acetyl-5-(4-cyano-phenyl)-2-(5-nitrofuran-2-yl)-2,3-dihydro-1,3,4-oxadiazole
CAS No.:1449763-68-1
Molecular Formula:C₁₅H₁₀N₄O₅
Molecular Weight:326.268
Hs Code.:

Synonyms:3-acetyl-5-(4-cyano-phenyl)-2-(5-nitrofuran-2-yl)-2,3-dihydro-1,3,4-oxadiazole

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Chemical Property of 3-acetyl-5-(4-cyano-phenyl)-2-(5-nitrofuran-2-yl)-2,3-dihydro-1,3,4-oxadiazole

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Technology Process of 3-acetyl-5-(4-cyano-phenyl)-2-(5-nitrofuran-2-yl)-2,3-dihydro-1,3,4-oxadiazole

There total 4 articles about 3-acetyl-5-(4-cyano-phenyl)-2-(5-nitrofuran-2-yl)-2,3-dihydro-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 19731-20-5
4-cyano-N’-((5-nitrofuran-2-yl)methylene)benzohydrazide

: 108-24-7
acetic anhydride

: 1449763-68-1
3-acetyl-5-(4-cyano-phenyl)-2-(5-nitrofuran-2-yl)-2,3-dihydro-1,3,4-oxadiazole

Guidance literature:: at 110 - 120 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.bmc.2013.06.017

Reference yield:

: 619-65-8,333406-09-0
4-cyanobenzoic Acid

: 1449763-68-1
3-acetyl-5-(4-cyano-phenyl)-2-(5-nitrofuran-2-yl)-2,3-dihydro-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / 4 h / Reflux

2: hydrazine hydrate / water / 0.5 h / Reflux

3: sulfuric acid; acetic acid / water; methanol / 1 h / Reflux

4: 12 h / 110 - 120 °C / Inert atmosphere

With sulfuric acid; hydrazine hydrate; acetic acid; In methanol; water;
DOI:10.1016/j.bmc.2013.06.017

Reference yield:

: 1129-35-7
4-cyanobenzoic acid methyl ester

: 1449763-68-1
3-acetyl-5-(4-cyano-phenyl)-2-(5-nitrofuran-2-yl)-2,3-dihydro-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / water / 0.5 h / Reflux

2: sulfuric acid; acetic acid / water; methanol / 1 h / Reflux

3: 12 h / 110 - 120 °C / Inert atmosphere

With sulfuric acid; hydrazine hydrate; acetic acid; In methanol; water;
DOI:10.1016/j.bmc.2013.06.017