Ethoxy-[2-(5-methyl-2-phenyl-oxazol-4-ylmethyl)-benzofuran-5-yl]-acetonitrile

Base Information

Chemical Name:Ethoxy-[2-(5-methyl-2-phenyl-oxazol-4-ylmethyl)-benzofuran-5-yl]-acetonitrile
CAS No.:181931-92-0
Molecular Formula:C₂₃H₂₀N₂O₃
Molecular Weight:372.423
Hs Code.:

Synonyms:Ethoxy-[2-(5-methyl-2-phenyl-oxazol-4-ylmethyl)-benzofuran-5-yl]-acetonitrile

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Chemical Property of Ethoxy-[2-(5-methyl-2-phenyl-oxazol-4-ylmethyl)-benzofuran-5-yl]-acetonitrile

Chemical Property:

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Technology Process of Ethoxy-[2-(5-methyl-2-phenyl-oxazol-4-ylmethyl)-benzofuran-5-yl]-acetonitrile

There total 6 articles about Ethoxy-[2-(5-methyl-2-phenyl-oxazol-4-ylmethyl)-benzofuran-5-yl]-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 7677-24-9
trimethylsilyl cyanide

: 181931-88-4
4-(5-Diethoxymethyl-benzofuran-2-ylmethyl)-5-methyl-2-phenyl-oxazole

: 181931-92-0
Ethoxy-[2-(5-methyl-2-phenyl-oxazol-4-ylmethyl)-benzofuran-5-yl]-acetonitrile

Guidance literature:: With boron trifluoride diethyl etherate; for 0.25h;
DOI:10.1021/jm960230h

Reference yield:

: 60032-63-5
4-hydroxy-3-iodo-benzaldehyde

: 181931-92-0
Ethoxy-[2-(5-methyl-2-phenyl-oxazol-4-ylmethyl)-benzofuran-5-yl]-acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 65 percent / Cu₂O, (PPh₃)2PdCl₂, pyridine / Heating

2: 69 percent / Amberlyst 15 / CH₂Cl₂ / 2 h / Heating

3: 74 percent / BF₃*Et₂O / 0.25 h

With pyridine; copper(I) oxide; bis-triphenylphosphine-palladium(II) chloride; Amberlyst 15; boron trifluoride diethyl etherate; In dichloromethane;
DOI:10.1021/jm960230h

Reference yield:

: 6813-61-2
2-(benzoylamino)-4-pentynoic acid

: 181931-92-0
Ethoxy-[2-(5-methyl-2-phenyl-oxazol-4-ylmethyl)-benzofuran-5-yl]-acetonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) pyridine, 2.) H₂O / 1.) 90 deg c, 1 h, 2.) from 85 to 90 deg C, 20 min

2: trifluoroacetic acid anhydride / trifluoroacetic acid / 6 h / 35 - 40 °C

3: 65 percent / Cu₂O, (PPh₃)2PdCl₂, pyridine / Heating

4: 69 percent / Amberlyst 15 / CH₂Cl₂ / 2 h / Heating

5: 74 percent / BF₃*Et₂O / 0.25 h

With pyridine; copper(I) oxide; bis-triphenylphosphine-palladium(II) chloride; Amberlyst 15; boron trifluoride diethyl etherate; water; trifluoroacetic anhydride; In dichloromethane; trifluoroacetic acid;
DOI:10.1021/jm960230h