1-(4-Fluoro-phenyl)-4-(4-hydroxy-2-phenyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-butan-1-one

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Chemical Name:1-(4-Fluoro-phenyl)-4-(4-hydroxy-2-phenyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-butan-1-one
CAS No.:109229-00-7
Molecular Formula:C₂₃H₂₂FN₃O₂
Molecular Weight:391.445
Hs Code.:

Synonyms:1-(4-Fluoro-phenyl)-4-(4-hydroxy-2-phenyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-butan-1-one

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Chemical Property of 1-(4-Fluoro-phenyl)-4-(4-hydroxy-2-phenyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-butan-1-one

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Technology Process of 1-(4-Fluoro-phenyl)-4-(4-hydroxy-2-phenyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-butan-1-one

There total 9 articles about 1-(4-Fluoro-phenyl)-4-(4-hydroxy-2-phenyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-butan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 109229-11-0
2-Phenyl-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-ol; hydrochloride

: 3874-54-2,41167-07-1
4-(4-fluorophenyl)-4-oxo-n-butyl chloride

: 109229-00-7
1-(4-Fluoro-phenyl)-4-(4-hydroxy-2-phenyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-butan-1-one

Guidance literature:: With sodium carbonate; In toluene; for 100h; Heating;

Reference yield:

: 41276-30-6
C₉H₁₄O₃NC₆H₅

: 109229-00-7
1-(4-Fluoro-phenyl)-4-(4-hydroxy-2-phenyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-butan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / K₂CO₃ / H₂O / 40 °C

2: 45 percent / toluene / 5 h / Heating

3: 90 percent / HCl(conc.) / H₂O / 8 h / Heating

4: 25 percent / Na₂CO₃ / toluene / 100 h / Heating

With hydrogenchloride; sodium carbonate; potassium carbonate; In water; toluene;

Reference yield:

: 793-19-1
bis(2-methoxycarbonylethyl)benzylamine

: 109229-00-7
6-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-2-phenyl-5,6,7,8-tetrahydro-3H-pyrido[4,3-d]pyrimidin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: sodium methoxide / 3 h / 100 °C / in xylene or toluene

2: 92 percent / hydrogen / 10 percent Pd/C / aq. acetic acid

3: sodium ethoxide / ethanol / 12 h / 100 °C

4: sodium carbonate, sodium iodide / various solvent(s) / 120 °C

With hydrogen; sodium methylate; sodium ethanolate; sodium carbonate; sodium iodide; palladium on activated charcoal; In ethanol; acetic acid;
DOI:10.1002/jhet.5570270708