diphenylmethyl 7-(2-thienylacetamido)-2α-methyl-3-(1-methyl-1H-tetrazol-5-yl)thiomethylceph-3-em-4-carboxylate

Base Information

Chemical Name:diphenylmethyl 7-(2-thienylacetamido)-2α-methyl-3-(1-methyl-1H-tetrazol-5-yl)thiomethylceph-3-em-4-carboxylate
CAS No.:80366-19-4
Molecular Formula:C₃₀H₂₈N₆O₄S₃
Molecular Weight:632.788
Hs Code.:

Synonyms:diphenylmethyl 7-(2-thienylacetamido)-2α-methyl-3-(1-methyl-1H-tetrazol-5-yl)thiomethylceph-3-em-4-carboxylate

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Chemical Property of diphenylmethyl 7-(2-thienylacetamido)-2α-methyl-3-(1-methyl-1H-tetrazol-5-yl)thiomethylceph-3-em-4-carboxylate

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Technology Process of diphenylmethyl 7-(2-thienylacetamido)-2α-methyl-3-(1-methyl-1H-tetrazol-5-yl)thiomethylceph-3-em-4-carboxylate

There total 6 articles about diphenylmethyl 7-(2-thienylacetamido)-2α-methyl-3-(1-methyl-1H-tetrazol-5-yl)thiomethylceph-3-em-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 80377-40-8
4-(1,1-diphenylmethylcarbonyl)-7-(2-thienylacetamido)-2α-methyl-3-(1-methyl-1H-tetrazol-5-yl)thiomethylceph-3-em 1-oxide

: 80366-19-4
diphenylmethyl 7-(2-thienylacetamido)-2α-methyl-3-(1-methyl-1H-tetrazol-5-yl)thiomethylceph-3-em-4-carboxylate

Guidance literature:: With phosphorus trichloride; In N,N-dimethyl-formamide; at -10 ℃; for 0.25h;
DOI:10.1248/cpb.31.1482

Reference yield:

: 70056-19-8
diphenylmethyl 7-(2-thienylacetamido)-2-methylene-3-acetoxymethylceph-3-em-4-carboxylate

: 80366-19-4
diphenylmethyl 7-(2-thienylacetamido)-2α-methyl-3-(1-methyl-1H-tetrazol-5-yl)thiomethylceph-3-em-4-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 57 percent / Zn, formic acid / dimethylformamide / 20 h / Ambient temperature

2: 62 percent / 2 N HCl / dimethylformamide / 20 h / Ambient temperature

3: SOCl₂, pyridine / CH₂Cl₂ / 0.5 h / -10 °C

4: 55 percent / dimethylformamide / Ambient temperature

5: 47 percent / MCPBA / CH₂Cl₂ / 1 h / -10 °C

6: 71 percent / PCl₃ / dimethylformamide / 0.25 h / -10 °C

With pyridine; hydrogenchloride; formic acid; thionyl chloride; 3-chloro-benzenecarboperoxoic acid; zinc; phosphorus trichloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.31.1482

Reference yield:

: 80366-17-2
diphenylmethyl 7-(2-thienylacetamido)-2-methyl-3-hydroxymethyl-ceph-2-em-4-carboxylate

: 80366-19-4
diphenylmethyl 7-(2-thienylacetamido)-2α-methyl-3-(1-methyl-1H-tetrazol-5-yl)thiomethylceph-3-em-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂, pyridine / CH₂Cl₂ / 0.5 h / -10 °C

2: 55 percent / dimethylformamide / Ambient temperature

3: 47 percent / MCPBA / CH₂Cl₂ / 1 h / -10 °C

4: 71 percent / PCl₃ / dimethylformamide / 0.25 h / -10 °C

With pyridine; thionyl chloride; 3-chloro-benzenecarboperoxoic acid; phosphorus trichloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.31.1482