<3(2R),4S>-3-<2--N-methylamino>-3-methoxy-1-oxopropyl>-4-(phenylmethyl)-2-oxazolidinone

Base Information

Chemical Name:<3(2R),4S>-3-<2--N-methylamino>-3-methoxy-1-oxopropyl>-4-(phenylmethyl)-2-oxazolidinone
CAS No.:139462-23-0
Molecular Formula:C₂₃H₂₆N₂O₆
Molecular Weight:426.469
Hs Code.:

<3(2R),4S>-3-<2-<N-<(phenylmethoxy)carbonyl>-N-methylamino>-3-methoxy-1-oxopropyl>-4-(phenylmethyl)-2-oxazolidinone

Synonyms:<3(2R),4S>-3-<2--N-methylamino>-3-methoxy-1-oxopropyl>-4-(phenylmethyl)-2-oxazolidinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of <3(2R),4S>-3-<2--N-methylamino>-3-methoxy-1-oxopropyl>-4-(phenylmethyl)-2-oxazolidinone

Chemical Property:

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Technology Process of <3(2R),4S>-3-<2--N-methylamino>-3-methoxy-1-oxopropyl>-4-(phenylmethyl)-2-oxazolidinone

There total 6 articles about <3(2R),4S>-3-<2--N-methylamino>-3-methoxy-1-oxopropyl>-4-(phenylmethyl)-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 39608-31-6
N-(Benzyloxycarbonyl)sarcosine

: 139462-23-0
<3(2R),4S>-3-<2--N-methylamino>-3-methoxy-1-oxopropyl>-4-(phenylmethyl)-2-oxazolidinone

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / diethyl ether / 1 h / 0 °C

2: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 2.) THF, hexane, a) -78 deg C, 15 min, b) 0 deg C, 30 min

3: 1.) TiCl₄, diisopropylethylamine, 2.) BF₃*Et₂O / 1.) CH₂Cl₂, 0 deg C, 3 h, 2.) CH₂Cl₂, 25 deg C, 2 h

With n-butyllithium; boron trifluoride diethyl etherate; titanium tetrachloride; triethylamine; N-ethyl-N,N-diisopropylamine; In diethyl ether;
DOI:10.1021/ja00050a024

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 139462-23-0
<3(2R),4S>-3-<2--N-methylamino>-3-methoxy-1-oxopropyl>-4-(phenylmethyl)-2-oxazolidinone

Guidance literature:: Multi-step reaction with 4 steps

1: NaOH / H₂O / 0.5 h / 25 °C

2: Et₃N / diethyl ether / 1 h / 0 °C

3: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 2.) THF, hexane, a) -78 deg C, 15 min, b) 0 deg C, 30 min

4: 1.) TiCl₄, diisopropylethylamine, 2.) BF₃*Et₂O / 1.) CH₂Cl₂, 0 deg C, 3 h, 2.) CH₂Cl₂, 25 deg C, 2 h

With sodium hydroxide; n-butyllithium; boron trifluoride diethyl etherate; titanium tetrachloride; triethylamine; N-ethyl-N,N-diisopropylamine; In diethyl ether; water;
DOI:10.1021/ja00050a024

Reference yield:

: C₁₆H₂₁NO₅

: 139462-23-0
<3(2R),4S>-3-<2--N-methylamino>-3-methoxy-1-oxopropyl>-4-(phenylmethyl)-2-oxazolidinone

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 2.) THF, hexane, a) -78 deg C, 15 min, b) 0 deg C, 30 min

2: 1.) TiCl₄, diisopropylethylamine, 2.) BF₃*Et₂O / 1.) CH₂Cl₂, 0 deg C, 3 h, 2.) CH₂Cl₂, 25 deg C, 2 h

With n-butyllithium; boron trifluoride diethyl etherate; titanium tetrachloride; N-ethyl-N,N-diisopropylamine;
DOI:10.1021/ja00050a024