(R)-ethyl 1-(3-(2-nitrophenyl)propanoyl)piperidine-2-carboxylate

Base Information

• Chemical Name: (R)-ethyl 1-(3-(2-nitrophenyl)propanoyl)piperidine-2-carboxylate
• CAS No.: 1417827-00-9
• Molecular Formula: C₁₇H₂₂N₂O₅
• Molecular Weight: 334.372
• Mol file: 1417827-00-9.mol

Synonyms:(R)-ethyl 1-(3-(2-nitrophenyl)propanoyl)piperidine-2-carboxylate

Chemical Property of (R)-ethyl 1-(3-(2-nitrophenyl)propanoyl)piperidine-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (R)-ethyl 1-(3-(2-nitrophenyl)propanoyl)piperidine-2-carboxylate

There total 4 articles about (R)-ethyl 1-(3-(2-nitrophenyl)propanoyl)piperidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

C30H28N3O7Pol + benzyl chloroformate (501-53-1,94274-21-2) + ethyl pipecolate (15862-72-3) → (S)-1-benzyloxycarbonyl-piperidine-2-carboxylic acid monoethyl ester + (R)-1-benzyloxycarbonyl-piperidine-2-carboxylic acid monoethyl ester + (R)-ethyl 1-(3-(2-nitrophenyl)propanoyl)piperidine-2-carboxylate (1417827-00-9) + (S)-ethyl 1-(3-(2-nitrophenyl)propanoyl)piperidine-2-carboxylate

Guidance literature:

C₃₀H₂₈N₃O₇Pol; ethyl pipecolate; In dichloromethane; for 48h;

benzyl chloroformate; With triethylamine; In dichloromethane; for 8h;

Reference yield:

C21H19N2O6Pol + C17H18NO4Pol + ethyl pipecolate (15862-72-3) → (R)-ethyl 1-(3-(2-nitrophenyl)propanoyl)piperidine-2-carboxylate (1417827-00-9) + (S)-ethyl 1-(3-(2-nitrophenyl)propanoyl)piperidine-2-carboxylate + C13H21NO3

Guidance literature:

In tetrahydrofuran; at 45 ℃; not specified Resolution of racemate; Flow reactor;

DOI:10.1038/nchem.2681

Reference yield:

C30H28N3O7Pol + ethyl pipecolate (15862-72-3) → (R)-ethyl 1-(3-(2-nitrophenyl)propanoyl)piperidine-2-carboxylate (1417827-00-9) + (S)-ethyl 1-(3-(2-nitrophenyl)propanoyl)piperidine-2-carboxylate + (S)-piperidine-2-carboxylic acid ethyl ester (22328-78-5) + piperidine-2(R)-yl carboxylic acid ethyl ester (22328-77-4)

Guidance literature:

In dichloromethane; at 23 ℃; for 48h; aminomethyl polystyrene resin Inert atmosphere; Resolution of racemate;

DOI:10.1002/anie.201204991

upstream raw materials:

ethyl pipecolate

benzyl chloroformate