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Usage

Uses

Used in Pharmaceutical Industry:
Ethyl (R)-Piperidine-2-Carboxylate is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs and molecules with potential therapeutic applications.
Used in Organic Chemistry:
Ethyl (R)-Piperidine-2-Carboxylate is used as a versatile building block in organic chemistry reactions, enabling the creation of a wide range of organic compounds for research and commercial purposes.
It is important to handle Ethyl (R)-Piperidine-2-Carboxylate with care and follow proper safety procedures to mitigate any health and safety risks associated with its use.

Upstream product

• 15862-72-3 ethyl pipecolate 
• 1346681-71-7 (1E)-4-hydroxy-1-mesityl-4-methylpent-1-en-3-one 

Downstream Products

• 184043-13-8 [5-(3-nitroguanidino)-2(S)-(3-(1-methyl-1-phenylethyl)benzenesulfonylamino)pentanoyl]piperidine-2(R)-carboxylic acid ethyl ester 
• 184043-14-9 N-[4-(3-nitroguanidino)-1(S)-(2(R)-hydroxymethylpiperidin-1-ylcarbonyl)butyl]-3-(1-methyl-1-phenylethyl)benzenesulfonamde 

Relevant academic research and scientific papers

Expanded substrate scope and catalyst optimization for the catalytic kinetic resolution of N-heterocycles

The scope, reactivity, and selectivity of the chiral hydroxamic acid-catalyzed kinetic resolution of chiral amines are improved by a new catalyst structure and a more environmentally friendly reaction protocol. In addition to increasing selectivity across all substrates, these conditions make possible the resolution of N-heterocycles containing lactams or other basic functional groups that can inhibit the catalyst.

Catalytic kinetic resolution of cyclic secondary amines

The catalytic resolution of racemic cyclic amines has been achieved by an enantioselective amidation reaction featuring an achiral N-heterocyclic carbene catalyst and a new chiral hydroxamic acid cocatalyst working in concert. The reactions proceed at room temperature, do not generate nonvolatile byproducts, and provide enantioenriched amines by aqueous extraction.