Technology Process of (S)-5-(4-propoxyphenyl)morpholin-3-one
There total 11 articles about (S)-5-(4-propoxyphenyl)morpholin-3-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(S)-ethyl 2-(2-(tert-butoxycarbonylamino)-2-(4-propoxyphenyl)ethoxy)acetate;
With
trifluoroacetic acid;
In
dichloromethane;
With
potassium carbonate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran;
at 50 ℃;
for 18h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: potassium carbonate / acetonitrile / 18 h / Reflux
2.1: hydroxylamine hydrochloride; sodium acetate / ethanol / 18 h / Reflux
3.1: hydrogen; ammonia / Raney nickel / ethanol; methanol / 20 h / 4395.87 Torr
4.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C
4.2: 0 °C
5.1: triethylamine / dichloromethane / 3 h / 20 °C
6.1: Chiralpak IA / ethyl acetate; hexane / Resolution of racemate
7.1: caesium carbonate / acetonitrile / 2 h / 100 °C
8.1: trifluoroacetic acid / dichloromethane
8.2: 18 h / 50 °C
With
lithium aluminium tetrahydride; hydroxylamine hydrochloride; ammonia; hydrogen; sodium acetate; potassium carbonate; caesium carbonate; triethylamine; trifluoroacetic acid;
Raney nickel;
In
tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; ethyl acetate; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: aluminum (III) chloride / dichloromethane / 0.75 h / 0 °C
1.2: 15.5 h / 0 - 20 °C
1.3: Cooling
2.1: potassium carbonate / acetonitrile / 18 h / Reflux
3.1: hydroxylamine hydrochloride; sodium acetate / ethanol / 18 h / Reflux
4.1: hydrogen; ammonia / Raney nickel / ethanol; methanol / 20 h / 4395.87 Torr
5.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C
5.2: 0 °C
6.1: triethylamine / dichloromethane / 3 h / 20 °C
7.1: Chiralpak IA / ethyl acetate; hexane / Resolution of racemate
8.1: caesium carbonate / acetonitrile / 2 h / 100 °C
9.1: trifluoroacetic acid / dichloromethane
9.2: 18 h / 50 °C
With
aluminum (III) chloride; lithium aluminium tetrahydride; hydroxylamine hydrochloride; ammonia; hydrogen; sodium acetate; potassium carbonate; caesium carbonate; triethylamine; trifluoroacetic acid;
Raney nickel;
In
tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; ethyl acetate; acetonitrile;
