1-(4-(dicyclohexylphosphino)phenyl)-4,5-dimethyl-1H-imidazole

Base Information

• Chemical Name: 1-(4-(dicyclohexylphosphino)phenyl)-4,5-dimethyl-1H-imidazole
• CAS No.: 1375061-27-0
• Molecular Formula: C₂₃H₃₃N₂P
• Molecular Weight: 368.502
• Mol file: 1375061-27-0.mol

Synonyms:1-(4-(dicyclohexylphosphino)phenyl)-4,5-dimethyl-1H-imidazole

Chemical Property of 1-(4-(dicyclohexylphosphino)phenyl)-4,5-dimethyl-1H-imidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-(dicyclohexylphosphino)phenyl)-4,5-dimethyl-1H-imidazole

There total 2 articles about 1-(4-(dicyclohexylphosphino)phenyl)-4,5-dimethyl-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

1-(4-iodophenyl)-4,5-dimethyl-1H-imidazole (1374036-95-9) + borane dicyclohexylphosphine → 1-(4-(dicyclohexylphosphino)phenyl)-4,5-dimethyl-1H-imidazole (1375061-27-0)

Guidance literature:

With potassium acetate; palladium diacetate; In ISOPROPYLAMIDE; at 130 ℃; for 3h; Inert atmosphere;

DOI:10.1021/om300145d

Reference yield:

p-aminoiodobenzene (540-37-4) → 1-(4-(dicyclohexylphosphino)phenyl)-4,5-dimethyl-1H-imidazole (1375061-27-0)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium chloride / Inert atmosphere

2: potassium acetate; palladium diacetate / ISOPROPYLAMIDE / 3 h / 130 °C / Inert atmosphere

With potassium acetate; palladium diacetate; ammonium chloride; In ISOPROPYLAMIDE; 2: Stelzer coupling;

DOI:10.1021/om300145d

Reference yield: 65.0%

1-(4-(dicyclohexylphosphino)phenyl)-4,5-dimethyl-1H-imidazole (1375061-27-0) + di(2-furyl)chlorophosphine (181257-35-2) → 1-(4-(dicyclohexylphosphino)phenyl)-2-(di-2-furylphosphino)-4,5-dimethyl-1H-imidazole (1375061-32-7)

Guidance literature:

1-(4-(dicyclohexylphosphino)phenyl)-4,5-dimethyl-1H-imidazole; With lithium diisopropyl amide; In diethyl ether; at -30 - 20 ℃; Inert atmosphere;

di(2-furyl)chlorophosphine; In diethyl ether; at -30 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/om300145d

upstream raw materials:

1-(4-iodophenyl)-4,5-dimethyl-1H-imidazole

p-aminoiodobenzene

Downstream raw materials:

1-(4-(dicyclohexylphosphino)phenyl)-2-(diphenylphosphino)-4,5-dimethyl-1H-imidazole

1-(4-(dicyclohexylphosphino)phenyl)-2-(di-2-furylphosphino)-4,5-dimethyl-1H-imidazole

1-(4-(dicyclohexylphosphino)phenyl)-2-(dicyclohexylphosphino)-4,5-dimethyl-1H-imidazole