2-(1-(4-fluorophenyl)ethyl)-7-(methylthio)thiazolo[5,4-d]-pyrimidin-5-amine

Base Information

Chemical Name:2-(1-(4-fluorophenyl)ethyl)-7-(methylthio)thiazolo[5,4-d]-pyrimidin-5-amine
CAS No.:1245317-29-6
Molecular Formula:C₁₄H₁₃FN₄S₂
Molecular Weight:320.414
Hs Code.:

Synonyms:2-(1-(4-fluorophenyl)ethyl)-7-(methylthio)thiazolo[5,4-d]-pyrimidin-5-amine

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Chemical Property of 2-(1-(4-fluorophenyl)ethyl)-7-(methylthio)thiazolo[5,4-d]-pyrimidin-5-amine

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Technology Process of 2-(1-(4-fluorophenyl)ethyl)-7-(methylthio)thiazolo[5,4-d]-pyrimidin-5-amine

There total 5 articles about 2-(1-(4-fluorophenyl)ethyl)-7-(methylthio)thiazolo[5,4-d]-pyrimidin-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1245316-51-1
2-(4-fluorobenzyl)-7-(methylthio)thiazolo[5,4-d]pyrimidin-5-amine

: 74-88-4
methyl iodide

: 1245317-29-6
2-(1-(4-fluorophenyl)ethyl)-7-(methylthio)thiazolo[5,4-d]-pyrimidin-5-amine

Guidance literature:: With sodium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 2h;
DOI:10.1021/jm101254z

Reference yield:

: 1245316-29-3
N-(2-amino-4,6-dihydroxypyrimidin-5-yl)-2-(4-fluorophenyl)acetamide

: 1245317-29-6
2-(1-(4-fluorophenyl)ethyl)-7-(methylthio)thiazolo[5,4-d]-pyrimidin-5-amine

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; tetraphosphorus decasulfide / 6 h / Reflux

2: triethylamine / dimethyl sulfoxide / 12 h / 25 °C / Inert atmosphere

3: sodium hydroxide / dimethyl sulfoxide / 2 h / 20 °C

With pyridine; tetraphosphorus decasulfide; triethylamine; sodium hydroxide; In dimethyl sulfoxide;
DOI:10.1021/jm101254z

Reference yield:

: 1245316-42-0
5-amino-2-(4-fluorobenzyl)thiazolo[5,4-d]pyrimidine-7-thiol

: 1245317-29-6
2-(1-(4-fluorophenyl)ethyl)-7-(methylthio)thiazolo[5,4-d]-pyrimidin-5-amine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dimethyl sulfoxide / 12 h / 25 °C / Inert atmosphere

2: sodium hydroxide / dimethyl sulfoxide / 2 h / 20 °C

With triethylamine; sodium hydroxide; In dimethyl sulfoxide;
DOI:10.1021/jm101254z