2-<<<(4-bromo-2-fluorophenyl)methyl>amino>sulfonyl>-α-cyano-β-oxobenzenepropanoic acid ethyl ester

Base Information

Chemical Name:2-<<<(4-bromo-2-fluorophenyl)methyl>amino>sulfonyl>-α-cyano-β-oxobenzenepropanoic acid ethyl ester
CAS No.:127526-30-1
Molecular Formula:C₁₉H₁₆BrFN₂O₅S
Molecular Weight:483.315
Hs Code.:

Synonyms:2-<<<(4-bromo-2-fluorophenyl)methyl>amino>sulfonyl>-α-cyano-β-oxobenzenepropanoic acid ethyl ester

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Chemical Property of 2-<<<(4-bromo-2-fluorophenyl)methyl>amino>sulfonyl>-α-cyano-β-oxobenzenepropanoic acid ethyl ester

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Technology Process of 2-<<<(4-bromo-2-fluorophenyl)methyl>amino>sulfonyl>-α-cyano-β-oxobenzenepropanoic acid ethyl ester

There total 3 articles about 2-<<<(4-bromo-2-fluorophenyl)methyl>amino>sulfonyl>-α-cyano-β-oxobenzenepropanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 128-44-9
saccharin sodium salt

: 127526-30-1
2-<<<(4-bromo-2-fluorophenyl)methyl>amino>sulfonyl>-α-cyano-β-oxobenzenepropanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / dimethylformamide / 1 h / 100 °C

2: 1.) potassium tert-butoxide / 1.) THF, 60 deg C, 45 min, 2.) THF, reflux, 3 h

With potassium tert-butylate; In N,N-dimethyl-formamide;
DOI:10.1021/jm00102a016

Reference yield:

: 76283-09-5
4-bromo-2-fluorobenzyl bromide

: 127526-30-1
2-<<<(4-bromo-2-fluorophenyl)methyl>amino>sulfonyl>-α-cyano-β-oxobenzenepropanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / dimethylformamide / 1 h / 100 °C

2: 1.) potassium tert-butoxide / 1.) THF, 60 deg C, 45 min, 2.) THF, reflux, 3 h

With potassium tert-butylate; In N,N-dimethyl-formamide;
DOI:10.1021/jm00102a016

Reference yield:

: 127511-40-4
2-<(4-bromo-2-fluorophenyl)methyl>benzoisothiazolin-3-one 1,1-dioxide

: 105-56-6
ethyl 2-cyanoacetate

: 127526-30-1
2-<<<(4-bromo-2-fluorophenyl)methyl>amino>sulfonyl>-α-cyano-β-oxobenzenepropanoic acid ethyl ester

Guidance literature:: With potassium tert-butylate; Yield given. Multistep reaction; 1.) THF, 60 deg C, 45 min, 2.) THF, reflux, 3 h;
DOI:10.1021/jm00102a016