4-(4-benzyloxy-phenyl)-5-[2-(4-fluorophenoxy)-1-hydroxyethyl]-3-(4-fluorophenyl)oxazolidin-2-one

Base Information

Chemical Name:4-(4-benzyloxy-phenyl)-5-[2-(4-fluorophenoxy)-1-hydroxyethyl]-3-(4-fluorophenyl)oxazolidin-2-one
CAS No.:1011264-99-5
Molecular Formula:C₃₀H₂₅F₂NO₅
Molecular Weight:517.529
Hs Code.:

Synonyms:4-(4-benzyloxy-phenyl)-5-[2-(4-fluorophenoxy)-1-hydroxyethyl]-3-(4-fluorophenyl)oxazolidin-2-one

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Chemical Property of 4-(4-benzyloxy-phenyl)-5-[2-(4-fluorophenoxy)-1-hydroxyethyl]-3-(4-fluorophenyl)oxazolidin-2-one

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Technology Process of 4-(4-benzyloxy-phenyl)-5-[2-(4-fluorophenoxy)-1-hydroxyethyl]-3-(4-fluorophenyl)oxazolidin-2-one

There total 8 articles about 4-(4-benzyloxy-phenyl)-5-[2-(4-fluorophenoxy)-1-hydroxyethyl]-3-(4-fluorophenyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 371-41-5
4-Fluorophenol

: 1011264-98-4
C₂₄H₂₀FNO₄

: 1011264-99-5
4-(4-benzyloxy-phenyl)-5-[2-(4-fluorophenoxy)-1-hydroxyethyl]-3-(4-fluorophenyl)oxazolidin-2-one

Guidance literature:: With caesium carbonate; In dimethyl sulfoxide; at 70 ℃; for 3h;
DOI:10.1016/j.bmcl.2007.11.083

Reference yield: 35.0%

: 371-41-5
4-Fluorophenol

: 1053173-80-0
4-(4-benzyloxy-phenyl)-3-(4-fluorophenyl)-5-oxiranyl-oxazolidin-2-one

: 1011264-99-5
4-(4-benzyloxy-phenyl)-5-[2-(4-fluorophenoxy)-1-hydroxyethyl]-3-(4-fluorophenyl)oxazolidin-2-one

Guidance literature:: With sodium t-butanolate; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 4397-53-9
p-benzyloxybenzaldehyde

: 1011264-99-5
4-(4-benzyloxy-phenyl)-5-[2-(4-fluorophenoxy)-1-hydroxyethyl]-3-(4-fluorophenyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: L-proline / dimethyl sulfoxide / 96 h / 20 °C

2: triethylamine / dichloromethane / -78 - 20 °C

3: phenyltrimethylammonium tribromide / tetrahydrofuran / 0 - 20 °C

4: sodium tetrahydroborate / ethanol / 1 h / 0 °C

5: sodium t-butanolate / tetrahydrofuran / 1 h / 20 °C

6: sodium t-butanolate / tetrahydrofuran / 1 h / 20 °C

With sodium tetrahydroborate; phenyltrimethylammonium tribromide; triethylamine; sodium t-butanolate; L-proline; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide;