5S-[1-fluoro-2-(4-fluorophenoxy)ethyl]-3-(4-fluorophenyl)-4R-(4-hydroxyphenyl)oxazolidin-2-one

Base Information

Chemical Name:5S-[1-fluoro-2-(4-fluorophenoxy)ethyl]-3-(4-fluorophenyl)-4R-(4-hydroxyphenyl)oxazolidin-2-one
CAS No.:1053173-27-5
Molecular Formula:C₂₃H₁₈F₃NO₄
Molecular Weight:429.395
Hs Code.:

Synonyms:5S-[1-fluoro-2-(4-fluorophenoxy)ethyl]-3-(4-fluorophenyl)-4R-(4-hydroxyphenyl)oxazolidin-2-one

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Chemical Property of 5S-[1-fluoro-2-(4-fluorophenoxy)ethyl]-3-(4-fluorophenyl)-4R-(4-hydroxyphenyl)oxazolidin-2-one

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Technology Process of 5S-[1-fluoro-2-(4-fluorophenoxy)ethyl]-3-(4-fluorophenyl)-4R-(4-hydroxyphenyl)oxazolidin-2-one

There total 8 articles about 5S-[1-fluoro-2-(4-fluorophenoxy)ethyl]-3-(4-fluorophenyl)-4R-(4-hydroxyphenyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1011264-99-5
4-(4-benzyloxy-phenyl)-5-[2-(4-fluorophenoxy)-1-hydroxyethyl]-3-(4-fluorophenyl)oxazolidin-2-one

: 1053173-27-5
5S-[1-fluoro-2-(4-fluorophenoxy)ethyl]-3-(4-fluorophenyl)-4R-(4-hydroxyphenyl)oxazolidin-2-one

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield:

: 4397-53-9
p-benzyloxybenzaldehyde

: 1053173-27-5
5S-[1-fluoro-2-(4-fluorophenoxy)ethyl]-3-(4-fluorophenyl)-4R-(4-hydroxyphenyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: L-proline / dimethyl sulfoxide / 96 h / 20 °C

2: triethylamine / dichloromethane / -78 - 20 °C

3: phenyltrimethylammonium tribromide / tetrahydrofuran / 0 - 20 °C

4: sodium tetrahydroborate / ethanol / 1 h / 0 °C

5: sodium t-butanolate / tetrahydrofuran / 1 h / 20 °C

6: sodium t-butanolate / tetrahydrofuran / 1 h / 20 °C

7: diethylamino-sulfur trifluoride / dichloromethane / 1 h / 0 - 20 °C

With sodium tetrahydroborate; diethylamino-sulfur trifluoride; phenyltrimethylammonium tribromide; triethylamine; sodium t-butanolate; L-proline; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 371-40-4
4-fluoroaniline

: 1053173-27-5
5S-[1-fluoro-2-(4-fluorophenoxy)ethyl]-3-(4-fluorophenyl)-4R-(4-hydroxyphenyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: L-proline / dimethyl sulfoxide / 96 h / 20 °C

2: triethylamine / dichloromethane / -78 - 20 °C

3: phenyltrimethylammonium tribromide / tetrahydrofuran / 0 - 20 °C

4: sodium tetrahydroborate / ethanol / 1 h / 0 °C

5: sodium t-butanolate / tetrahydrofuran / 1 h / 20 °C

6: sodium t-butanolate / tetrahydrofuran / 1 h / 20 °C

7: diethylamino-sulfur trifluoride / dichloromethane / 1 h / 0 - 20 °C

With sodium tetrahydroborate; diethylamino-sulfur trifluoride; phenyltrimethylammonium tribromide; triethylamine; sodium t-butanolate; L-proline; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide;