1-[4-[2-[4-[bis(4-fluorophenyl)methyl]-1-piperidinyl]ethoxy]-3-methoxyphenyl]ethanone

Base Information

Chemical Name:1-[4-[2-[4-[bis(4-fluorophenyl)methyl]-1-piperidinyl]ethoxy]-3-methoxyphenyl]ethanone
CAS No.:111626-73-4
Molecular Formula:C₂₉H₃₁F₂NO₃
Molecular Weight:479.567
Hs Code.:

Synonyms:1-[4-[2-[4-[bis(4-fluorophenyl)methyl]-1-piperidinyl]ethoxy]-3-methoxyphenyl]ethanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[4-[2-[4-[bis(4-fluorophenyl)methyl]-1-piperidinyl]ethoxy]-3-methoxyphenyl]ethanone

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Technology Process of 1-[4-[2-[4-[bis(4-fluorophenyl)methyl]-1-piperidinyl]ethoxy]-3-methoxyphenyl]ethanone

There total 3 articles about 1-[4-[2-[4-[bis(4-fluorophenyl)methyl]-1-piperidinyl]ethoxy]-3-methoxyphenyl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 60285-00-9
4-[bis(4-fluorophenyl)-methyl]piperidine

: 3430-03-3
1-[4-(2-Chloroethoxy)-3-methoxyphenyl]ethanone

: 111626-73-4
1-[4-[2-[4-[bis(4-fluorophenyl)methyl]-1-piperidinyl]ethoxy]-3-methoxyphenyl]ethanone

Guidance literature:: With potassium carbonate; potassium iodide; In butan-1-ol; Heating;
DOI:10.1021/jm00114a009

Reference yield:

: 60285-00-9
4-[bis(4-fluorophenyl)-methyl]piperidine

: ethyl acetate n-hexane

: 3430-03-3
1-[4-(2-Chloroethoxy)-3-methoxyphenyl]ethanone

: 111626-73-4
1-[4-[2-[4-[bis(4-fluorophenyl)methyl]-1-piperidinyl]ethoxy]-3-methoxyphenyl]ethanone

Guidance literature:: With potassium iodide; potassium carbonate; In butan-1-ol;

Reference yield:

: 58113-36-3
4-(bis(4-fluorophenyl)methylene)piperidine

: 111626-73-4
1-[4-[2-[4-[bis(4-fluorophenyl)methyl]-1-piperidinyl]ethoxy]-3-methoxyphenyl]ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: I₂, phosphorous, methanesulfonic acid / aq. acetic acid / 7 h / Heating

2: 27 percent / K₂CO₃, KI / butan-1-ol / Heating

With phosphorus; methanesulfonic acid; iodine; potassium carbonate; potassium iodide; In acetic acid; butan-1-ol;
DOI:10.1021/jm00114a009