(S)-4-(4-(2-(1-aminocyclohexanecarboxamido)-2-cyanoethyl)phenyl)picolinamide trifluoroacetate

Base Information

Chemical Name:(S)-4-(4-(2-(1-aminocyclohexanecarboxamido)-2-cyanoethyl)phenyl)picolinamide trifluoroacetate
CAS No.:1352152-50-1
Molecular Formula:C₂HF₃O₂*C₂₂H₂₅N₅O₂
Molecular Weight:505.497
Hs Code.:

Synonyms:(S)-4-(4-(2-(1-aminocyclohexanecarboxamido)-2-cyanoethyl)phenyl)picolinamide trifluoroacetate

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Chemical Property of (S)-4-(4-(2-(1-aminocyclohexanecarboxamido)-2-cyanoethyl)phenyl)picolinamide trifluoroacetate

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Technology Process of (S)-4-(4-(2-(1-aminocyclohexanecarboxamido)-2-cyanoethyl)phenyl)picolinamide trifluoroacetate

There total 6 articles about (S)-4-(4-(2-(1-aminocyclohexanecarboxamido)-2-cyanoethyl)phenyl)picolinamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103882-09-3,62129-44-6
N-Boc-4-I-Phe-OH

: 1352152-50-1
(S)-4-(4-(2-(1-aminocyclohexanecarboxamido)-2-cyanoethyl)phenyl)picolinamide trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethylmorpholine; / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 16 h / 0 - 28 °C

2.1: trifluoroacetic acid / dichloromethane / 50 h

3.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 2 h / 17 - 28 °C

4.1: potassium acetate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / acetonitrile; water / 4 h / Reflux

5.1: Burgess Reagent / dichloromethane / 5 h / 17 - 28 °C

6.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile; water / 4 h / 90 °C / Inert atmosphere

7.1: formic acid / 4 h / 17 - 28 °C

With N-ethylmorpholine;; formic acid; Burgess Reagent; potassium acetate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 97964-72-2
(S)-2-amino-3-(4-iodophenyl)propionamamide

: 1352152-50-1
(S)-4-(4-(2-(1-aminocyclohexanecarboxamido)-2-cyanoethyl)phenyl)picolinamide trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 2 h / 17 - 28 °C

2: potassium acetate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / acetonitrile; water / 4 h / Reflux

3: Burgess Reagent / dichloromethane / 5 h / 17 - 28 °C

4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile; water / 4 h / 90 °C / Inert atmosphere

5: formic acid / 4 h / 17 - 28 °C

With formic acid; Burgess Reagent; potassium acetate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 868694-44-4
[(1S)-1-carbamoyl-2-(4-iodophenyl)ethyl]carbamic acid tert-butyl ester

: 1352152-50-1
(S)-4-(4-(2-(1-aminocyclohexanecarboxamido)-2-cyanoethyl)phenyl)picolinamide trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1: trifluoroacetic acid / dichloromethane / 50 h

2: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 2 h / 17 - 28 °C

3: potassium acetate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / acetonitrile; water / 4 h / Reflux

4: Burgess Reagent / dichloromethane / 5 h / 17 - 28 °C

5: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile; water / 4 h / 90 °C / Inert atmosphere

6: formic acid / 4 h / 17 - 28 °C

With formic acid; Burgess Reagent; potassium acetate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;