N-{6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]naphthalen-2-yl}-N'-methylurea

Base Information

Chemical Name:N-{6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]naphthalen-2-yl}-N'-methylurea
CAS No.:1285532-61-7
Molecular Formula:C₃₈H₃₆N₄O₂
Molecular Weight:580.729
Hs Code.:

Synonyms:N-{6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]naphthalen-2-yl}-N'-methylurea

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Chemical Property of N-{6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]naphthalen-2-yl}-N'-methylurea

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Technology Process of N-{6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]naphthalen-2-yl}-N'-methylurea

There total 7 articles about N-{6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]naphthalen-2-yl}-N'-methylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₃H₃₇N₃O₃

: 593-51-1
methylamine hydrochloride

: 1285532-61-7
N-{6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]naphthalen-2-yl}-N'-methylurea

Guidance literature:: C₄₃H₃₇N₃O₃; methylamine hydrochloride; In dimethyl sulfoxide; at 20 ℃; for 1h;

With water; sodium hydroxide; In dimethyl sulfoxide;
DOI:10.1016/j.bmc.2011.01.017

Reference yield:

: 15231-91-1
6-bromo-naphthalen-2-ol

: 1285532-61-7
N-{6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]naphthalen-2-yl}-N'-methylurea

Guidance literature:: Multi-step reaction with 6 steps

1.1: bromine; triphenylphosphine / acetonitrile / 2.5 h / 20 - 70 °C

1.2: 1 h / 300 °C / neat (no solvent)

2.1: n-butyllithium / tetrahydrofuran / 0.33 h / -50 °C

2.2: 0.67 h / -50 °C

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; sodium t-butanolate / toluene / 18 h / 80 °C / Inert atmosphere

4.1: hydroxylamine hydrochloride; sodium acetate / tetrahydrofuran; methanol / 0.67 h / 20 °C

5.1: pyridine / tetrahydrofuran / 0.5 h / 0 °C

6.1: dimethyl sulfoxide / 1 h / 20 °C

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; n-butyllithium; hydroxylamine hydrochloride; bromine; sodium acetate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; triphenylphosphine; sodium t-butanolate; In tetrahydrofuran; methanol; dimethyl sulfoxide; toluene; acetonitrile;
DOI:10.1016/j.bmc.2011.01.017

Reference yield:

: 247174-40-9
1-(6-amino-2-naphthyl)-2-methyl-1-(1-trityl-1H-imidazol-4-yl)-1-propanol

: 1285532-61-7
N-{6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]naphthalen-2-yl}-N'-methylurea

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / tetrahydrofuran / 0.5 h / 0 °C

2: dimethyl sulfoxide / 1 h / 20 °C

With pyridine; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1016/j.bmc.2011.01.017