Acetanilide, p-(2-cyanoethyl)- (4CI)

Base Information

• Chemical Name: Acetanilide, p-(2-cyanoethyl)- (4CI)
• CAS No.: 857624-43-2
• Molecular Formula: C₁₁H₁₂N₂O
• Molecular Weight: 188.229
• Mol file: 857624-43-2.mol

Synonyms:Acetanilide,p-(2-cyanoethyl)- (4CI)

Chemical Property of Acetanilide, p-(2-cyanoethyl)- (4CI)

Chemical Property:

• PSA: 52.89000
• LogP: 2.17418

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Acetanilide, p-(2-cyanoethyl)- (4CI)

There total 4 articles about Acetanilide, p-(2-cyanoethyl)- (4CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-(4-acetylphenyl)propionitrile oxime → N-[4-(2-cyanoethyl)phenyl]acetamide (857624-43-2)

Guidance literature:

With 1,1,1,3',3',3'-hexafluoro-propanol; perfluoropinacol; 2-(phenoxycarbonyl)phenylboronic acid; In nitromethane; at 20 ℃; for 24h; chemoselective reaction;

DOI:10.1021/jacs.8b01618

Reference yield: 78.0%

N-(4-(2-cyano-2-(phenylsulfonyl)ethyl)phenyl)acetamide. → N-[4-(2-cyanoethyl)phenyl]acetamide (857624-43-2)

Guidance literature:

With chloro-trimethyl-silane; bis(pentamethylcyclopentadienyl)titanium dichloride; 2,4,6-collidine hydrochloride; zinc(II) chloride; zinc; In toluene; at 110 ℃; for 24h; Inert atmosphere; Sealed tube;

DOI:10.1002/chem.202005400

Reference yield: 47.0%

(4-acetylaminophenyl)boronic acid (101251-09-6) + acrylonitrile (107-13-1,25014-41-9) → N-[4-(2-cyanoethyl)phenyl]acetamide (857624-43-2)

Guidance literature:

With terephthalonitrile; phenanthrene; sodium hydroxide; In water; acetonitrile; at 20 ℃; for 3h; Time; Inert atmosphere; Irradiation;

DOI:10.1039/c7cc09140k

upstream raw materials:

(4-acetylaminophenyl)boronic acid

acrylonitrile

para-acetamidobenzaldehyde