(1'S,2'R)-2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl thiolbenzoate

Base Information

Chemical Name:(1'S,2'R)-2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl thiolbenzoate
CAS No.:913288-77-4
Molecular Formula:C₃₂H₃₃NO₃S₂
Molecular Weight:543.751
Hs Code.:

Synonyms:(1'S,2'R)-2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl thiolbenzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1'S,2'R)-2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl thiolbenzoate

Chemical Property:

Purity/Quality:

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Technology Process of (1'S,2'R)-2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl thiolbenzoate

There total 6 articles about (1'S,2'R)-2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl thiolbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 37577-28-9,58550-13-3,757124-50-8
(1S,2R)-(+)-norphedrine

: 913288-77-4
(1'S,2'R)-2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl thiolbenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / Et₃N / CH₂Cl₂ / 2 h / 0 °C

2: 87 percent / methanesulfonylchloride; Et₃N / 14.17 h / 0 - 20 °C

3: 93 percent / PBu₃ / acetonitrile; H₂O / 18 h / 20 °C

4: NaH / dimethylformamide / 18 h / 20 °C

With tributylphosphine; sodium hydride; methanesulfonyl chloride; triethylamine; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ol0614774

Reference yield:

: 913288-76-3
(1'S,2'R)-2'-(N-mesitylenesulfonylamino)-1'-phenylpropyl thiolbenzoate

: 100-39-0
benzyl bromide

: 913288-77-4
(1'S,2'R)-2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl thiolbenzoate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1021/ol0614774

Reference yield:

: 773-64-8
2-mesitylenesulphonyl chloride

: 913288-77-4
(1'S,2'R)-2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl thiolbenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / Et₃N / CH₂Cl₂ / 2 h / 0 °C

2: 87 percent / methanesulfonylchloride; Et₃N / 14.17 h / 0 - 20 °C

3: 93 percent / PBu₃ / acetonitrile; H₂O / 18 h / 20 °C

4: NaH / dimethylformamide / 18 h / 20 °C

With tributylphosphine; sodium hydride; methanesulfonyl chloride; triethylamine; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ol0614774