methyl 7-fluoro-2-(4-fluorophenyl)-3-(1-methyl-1H-imidazol-2-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate

Base Information

Chemical Name:methyl 7-fluoro-2-(4-fluorophenyl)-3-(1-methyl-1H-imidazol-2-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate
CAS No.:1207453-96-0
Molecular Formula:C₂₁H₁₇F₂N₃O₃
Molecular Weight:397.381
Hs Code.:

Synonyms:methyl 7-fluoro-2-(4-fluorophenyl)-3-(1-methyl-1H-imidazol-2-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate

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Chemical Property of methyl 7-fluoro-2-(4-fluorophenyl)-3-(1-methyl-1H-imidazol-2-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate

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Technology Process of methyl 7-fluoro-2-(4-fluorophenyl)-3-(1-methyl-1H-imidazol-2-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate

There total 7 articles about methyl 7-fluoro-2-(4-fluorophenyl)-3-(1-methyl-1H-imidazol-2-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1207453-95-9
(E)-6-fluoro-4-(4-fluorobenzylideneamino)isobenzofuran-1(3H)-one

: 124-41-4
sodium methylate

: 105-37-3,20741-13-3
Ethyl propionate

: 13750-81-7
N-methyl-2-imidazolcarboxaldehyde

: 1207453-96-0
methyl 7-fluoro-2-(4-fluorophenyl)-3-(1-methyl-1H-imidazol-2-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate

Guidance literature:: In methanol; at 20 ℃;

Reference yield:

: 33184-16-6
5-fluoro-2-methylbenzoic acid

: 1207453-96-0
methyl 7-fluoro-2-(4-fluorophenyl)-3-(1-methyl-1H-imidazol-2-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: nitric acid / sulfuric acid / 3.5 h / -5 - 0 °C

2: thionyl chloride / methanol / 16 h / 0 °C / Reflux

3: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / Reflux

4: 1,4-dioxane; water / 96 h / Reflux

5: hydrogen / palladium 10% on activated carbon / ethyl acetate / 12 h / 25 °C / 760.05 Torr

6: magnesium sulfate / dichloromethane / Reflux

7: methanol / 20 °C

With N-Bromosuccinimide; thionyl chloride; hydrogen; nitric acid; magnesium sulfate; dibenzoyl peroxide; sulfuric acid; palladium 10% on activated carbon; In 1,4-dioxane; methanol; tetrachloromethane; dichloromethane; water; ethyl acetate;

Reference yield:

: 697739-03-0
5-fluoro-2-methyl-3-nitrobenzoic acid methyl ester

: 1207453-96-0
methyl 7-fluoro-2-(4-fluorophenyl)-3-(1-methyl-1H-imidazol-2-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / Reflux

2: 1,4-dioxane; water / 96 h / Reflux

3: hydrogen / palladium 10% on activated carbon / ethyl acetate / 12 h / 25 °C / 760.05 Torr

4: magnesium sulfate / dichloromethane / Reflux

5: methanol / 20 °C

With N-Bromosuccinimide; hydrogen; magnesium sulfate; dibenzoyl peroxide; palladium 10% on activated carbon; In 1,4-dioxane; methanol; tetrachloromethane; dichloromethane; water; ethyl acetate;