(2R)-2-[8-(2-Chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)purin-9-yl]propan-1-ol hydrochloride

Base Information

Chemical Name:(2R)-2-[8-(2-Chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)purin-9-yl]propan-1-ol hydrochloride
CAS No.:1335202-19-1
Molecular Formula:C₂₀H₂₅ClN₆O*ClH
Molecular Weight:437.372
Hs Code.:

Synonyms:(2R)-2-[8-(2-Chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)purin-9-yl]propan-1-ol hydrochloride

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Chemical Property of (2R)-2-[8-(2-Chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)purin-9-yl]propan-1-ol hydrochloride

Chemical Property:

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Technology Process of (2R)-2-[8-(2-Chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)purin-9-yl]propan-1-ol hydrochloride

There total 8 articles about (2R)-2-[8-(2-Chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)purin-9-yl]propan-1-ol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1335202-21-5
(2R)-2-[8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)purin-9-yl]propan-1-ol

: 1335202-19-1
(2R)-2-[8-(2-Chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)purin-9-yl]propan-1-ol hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; diethyl ether; at 20 ℃; for 2.5h;

Reference yield:

: 39906-04-2
5-amino-4,6-dichloro-2-methylpyrimidine

: 1335202-19-1
(2R)-2-[8-(2-Chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)purin-9-yl]propan-1-ol hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / isopropyl alcohol / 60.5 h / 50 °C / Reflux

2: triethylamine; nitrobenzene / dimethyl sulfoxide / 21.5 h / 20 - 140 °C

3: hydrogenchloride / 1,4-dioxane; diethyl ether / 2.5 h / 20 °C

With hydrogenchloride; nitrobenzene; triethylamine; In 1,4-dioxane; diethyl ether; dimethyl sulfoxide; isopropyl alcohol;

Reference yield:

: 609-65-4
o-chlorobenzoyl chloride

: 1335202-19-1
(2R)-2-[8-(2-Chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)purin-9-yl]propan-1-ol hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 1-methyl-pyrrolidin-2-one / 5 h / 80 °C

2: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 17 h / 80 °C

3: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 24 h / 160 °C / Parr autoclave; Sealed tube

4: hydrogenchloride / 1,4-dioxane; diethyl ether / 2.5 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; diethyl ether; isopropyl alcohol;