(2R)-2-[8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)purin-9-yl]propan-1-ol

Base Information

• Chemical Name: (2R)-2-[8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)purin-9-yl]propan-1-ol
• CAS No.: 1335202-21-5
• Molecular Formula: C₂₀H₂₅ClN₆O
• Molecular Weight: 400.911

Synonyms:(2R)-2-[8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)purin-9-yl]propan-1-ol

Chemical Property of (2R)-2-[8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)purin-9-yl]propan-1-ol

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Technology Process of (2R)-2-[8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)purin-9-yl]propan-1-ol

There total 6 articles about (2R)-2-[8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)purin-9-yl]propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methyl-piperazine (109-01-3) + 2-chloro-N-[4-chloro-6-[[(1R)-2-hydroxy-1-methyl-ethyl]amino]-2-methyl-pyrimidin-5-yl]benzamide (1335202-52-2) → (2R)-2-[8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)purin-9-yl]propan-1-ol (1335202-21-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 160 ℃; for 24h; Parr autoclave; Sealed tube;

Reference yield:

1-methyl-piperazine (109-01-3) + (2R)-2-[(5-amino-6-chloro-2-methyl-pyrimidin-4-yl)amino]propan-1-ol (1335202-50-0) + 2-chloro-benzaldehyde (89-98-5) → (2R)-2-[8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)purin-9-yl]propan-1-ol (1335202-21-5)

Guidance literature:

With nitrobenzene; triethylamine; In dimethyl sulfoxide; at 20 - 140 ℃; for 21.5h;

Reference yield:

(2R)-2-[8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)purin-9-yl]propan-1-ol oxalate salt (1335202-22-6) → (2R)-2-[8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)purin-9-yl]propan-1-ol (1335202-21-5)

Guidance literature:

With sodium hydroxide; In dichloromethane; water; for 0.333333h;

upstream raw materials:

o-chlorobenzoyl chloride

5-amino-4,6-dichloro-2-methylpyrimidine

1-methyl-piperazine

(2R)-2-[(5-amino-6-chloro-2-methyl-pyrimidin-4-yl)amino]propan-1-ol

Downstream raw materials:

(2R)-2-[8-(2-Chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)purin-9-yl]propan-1-ol hydrochloride

(2R)-2-[8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)purin-9-yl]propan-1-ol oxalate salt

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