Methyl 2-<2-(2-bromo-5-methoxyphenyl)ethyl>-1-methyl-3-oxocyclohexanecarboxylate

Base Information

Chemical Name:Methyl 2-<2-(2-bromo-5-methoxyphenyl)ethyl>-1-methyl-3-oxocyclohexanecarboxylate
CAS No.:198631-06-0
Molecular Formula:C₁₈H₂₃BrO₄
Molecular Weight:383.282
Hs Code.:

Synonyms:Methyl 2-<2-(2-bromo-5-methoxyphenyl)ethyl>-1-methyl-3-oxocyclohexanecarboxylate

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Chemical Property of Methyl 2-<2-(2-bromo-5-methoxyphenyl)ethyl>-1-methyl-3-oxocyclohexanecarboxylate

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Technology Process of Methyl 2-<2-(2-bromo-5-methoxyphenyl)ethyl>-1-methyl-3-oxocyclohexanecarboxylate

There total 11 articles about Methyl 2-<2-(2-bromo-5-methoxyphenyl)ethyl>-1-methyl-3-oxocyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 27060-75-9
4-bromo-3-methylanisole

: 198631-06-0
Methyl 2-<2-(2-bromo-5-methoxyphenyl)ethyl>-1-methyl-3-oxocyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 11 steps

1: 69 percent / Br₂, (PhCO₂)2 / CCl₄ / 1 h / Heating

2: dimethylsulfoxide / 0.75 h / Ambient temperature

3: aq. KOH / ethanol / 14 h / Heating

4: conc. H₂SO₄ / 7 h / Heating

5: 93 percent / LiAlH₄ / diethyl ether / 2 h / 25 - 30 °C

6: PBr₃ / benzene / 1.) r.t., overnight, 2.) 70-80 deg C, 2 h

7: 62 percent / t-BuOK / 2-methyl-propan-2-ol

8: 78 percent / aq. KOH / ethanol / 14 h / Heating

9: aq. ethanol / 14 h / Heating

10: aq. KOH / ethanol / 96 h / Heating

11: diethyl ether

With potassium hydroxide; lithium aluminium tetrahydride; sulfuric acid; potassium tert-butylate; bromine; phosphorus tribromide; dibenzoyl peroxide; In tetrachloromethane; diethyl ether; ethanol; dimethyl sulfoxide; tert-butyl alcohol; benzene;

Reference yield:

: 19614-12-1
2-bromo-5-methoxybenzyl bromide

: 198631-06-0
Methyl 2-<2-(2-bromo-5-methoxyphenyl)ethyl>-1-methyl-3-oxocyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 10 steps

1: dimethylsulfoxide / 0.75 h / Ambient temperature

2: aq. KOH / ethanol / 14 h / Heating

3: conc. H₂SO₄ / 7 h / Heating

4: 93 percent / LiAlH₄ / diethyl ether / 2 h / 25 - 30 °C

5: PBr₃ / benzene / 1.) r.t., overnight, 2.) 70-80 deg C, 2 h

6: 62 percent / t-BuOK / 2-methyl-propan-2-ol

7: 78 percent / aq. KOH / ethanol / 14 h / Heating

8: aq. ethanol / 14 h / Heating

9: aq. KOH / ethanol / 96 h / Heating

10: diethyl ether

With potassium hydroxide; lithium aluminium tetrahydride; sulfuric acid; potassium tert-butylate; phosphorus tribromide; In diethyl ether; ethanol; dimethyl sulfoxide; tert-butyl alcohol; benzene;

Reference yield:

: 27387-23-1
5-methoxy-2-bromophenylacetonitrile

: 198631-06-0
Methyl 2-<2-(2-bromo-5-methoxyphenyl)ethyl>-1-methyl-3-oxocyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 9 steps

1: aq. KOH / ethanol / 14 h / Heating

2: conc. H₂SO₄ / 7 h / Heating

3: 93 percent / LiAlH₄ / diethyl ether / 2 h / 25 - 30 °C

4: PBr₃ / benzene / 1.) r.t., overnight, 2.) 70-80 deg C, 2 h

5: 62 percent / t-BuOK / 2-methyl-propan-2-ol

6: 78 percent / aq. KOH / ethanol / 14 h / Heating

7: aq. ethanol / 14 h / Heating

8: aq. KOH / ethanol / 96 h / Heating

9: diethyl ether

With potassium hydroxide; lithium aluminium tetrahydride; sulfuric acid; potassium tert-butylate; phosphorus tribromide; In diethyl ether; ethanol; tert-butyl alcohol; benzene;