N⁴-benzyloxy-N¹-(cyclohexyl-methylcarbamoyl-methyl)-2-isobutyl-3-methyl-succinamide

Base Information

• Chemical Name: N⁴-benzyloxy-N¹-(cyclohexyl-methylcarbamoyl-methyl)-2-isobutyl-3-methyl-succinamide
• CAS No.: 205526-96-1
• Molecular Formula: C₂₅H₃₉N₃O₄
• Molecular Weight: 445.602

Synonyms:N⁴-benzyloxy-N¹-(cyclohexyl-methylcarbamoyl-methyl)-2-isobutyl-3-methyl-succinamide

Chemical Property of N⁴-benzyloxy-N¹-(cyclohexyl-methylcarbamoyl-methyl)-2-isobutyl-3-methyl-succinamide

Chemical Property:

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Technology Process of N⁴-benzyloxy-N¹-(cyclohexyl-methylcarbamoyl-methyl)-2-isobutyl-3-methyl-succinamide

There total 2 articles about N⁴-benzyloxy-N¹-(cyclohexyl-methylcarbamoyl-methyl)-2-isobutyl-3-methyl-succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-3-[((S)-Cyclohexyl-methylcarbamoyl-methyl)-carbamoyl]-5-methyl-2-methylene-hexanoic acid (188729-01-3) → N4-benzyloxy-N1-(cyclohexyl-methylcarbamoyl-methyl)-2-isobutyl-3-methyl-succinamide (205526-96-1)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 10 percent Pd/C / methanol / Ambient temperature

2: HOBT*H₂O, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, Et₃N / dimethylformamide / 12 h / Ambient temperature

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm970404a

Reference yield:

2-{(R)-1-[((S)-Cyclohexyl-methylcarbamoyl-methyl)-carbamoyl]-3-methyl-butyl}-malonic acid dibenzyl ester (188729-00-2) → N4-benzyloxy-N1-(cyclohexyl-methylcarbamoyl-methyl)-2-isobutyl-3-methyl-succinamide (205526-96-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) H₂, 2.) piperidine, H₂O / 1.) 10 percent Pd/C / 1.) EtOH, RT, 4 h, 2.) EtOH, a) RT, 16 h, b) reflux, 1 h

2: H₂ / 10 percent Pd/C / methanol / Ambient temperature

3: HOBT*H₂O, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, Et₃N / dimethylformamide / 12 h / Ambient temperature

With piperidine; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm970404a

Reference yield: 50.0%

N4-benzyloxy-N1-(cyclohexyl-methylcarbamoyl-methyl)-2-isobutyl-3-methyl-succinamide (205526-96-1) → KBR 7785

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; Ambient temperature;

DOI:10.1021/jm970404a

upstream raw materials:

(R)-3-[((S)-Cyclohexyl-methylcarbamoyl-methyl)-carbamoyl]-5-methyl-2-methylene-hexanoic acid

2-{(R)-1-[((S)-Cyclohexyl-methylcarbamoyl-methyl)-carbamoyl]-3-methyl-butyl}-malonic acid dibenzyl ester

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