(R)-3-[((S)-Cyclohexyl-methylcarbamoyl-methyl)-carbamoyl]-5-methyl-2-methylene-hexanoic acid

Base Information

• Chemical Name: (R)-3-[((S)-Cyclohexyl-methylcarbamoyl-methyl)-carbamoyl]-5-methyl-2-methylene-hexanoic acid
• CAS No.: 188729-01-3
• Molecular Formula: C₁₈H₃₀N₂O₄
• Molecular Weight: 338.447
• Mol file: 188729-01-3.mol

Synonyms:(R)-3-[((S)-Cyclohexyl-methylcarbamoyl-methyl)-carbamoyl]-5-methyl-2-methylene-hexanoic acid

Chemical Property of (R)-3-[((S)-Cyclohexyl-methylcarbamoyl-methyl)-carbamoyl]-5-methyl-2-methylene-hexanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-[((S)-Cyclohexyl-methylcarbamoyl-methyl)-carbamoyl]-5-methyl-2-methylene-hexanoic acid

There total 1 articles about (R)-3-[((S)-Cyclohexyl-methylcarbamoyl-methyl)-carbamoyl]-5-methyl-2-methylene-hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-{(R)-1-[((S)-Cyclohexyl-methylcarbamoyl-methyl)-carbamoyl]-3-methyl-butyl}-malonic acid dibenzyl ester (188729-00-2) → (R)-3-[((S)-Cyclohexyl-methylcarbamoyl-methyl)-carbamoyl]-5-methyl-2-methylene-hexanoic acid (188729-01-3)

Guidance literature:

With piperidine; water; hydrogen; palladium on activated charcoal; Yield given; Multistep reaction; 1.) EtOH, RT, 4 h, 2.) EtOH, a) RT, 16 h, b) reflux, 1 h;

DOI:10.1021/jm970404a

Reference yield:

(R)-3-[((S)-Cyclohexyl-methylcarbamoyl-methyl)-carbamoyl]-5-methyl-2-methylene-hexanoic acid (188729-01-3) → (R)-3-[((S)-Cyclohexyl-methylcarbamoyl-methyl)-carbamoyl]-2,5-dimethyl-hexanoic acid (205526-95-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; Ambient temperature;

DOI:10.1021/jm970404a

Reference yield:

(R)-3-[((S)-Cyclohexyl-methylcarbamoyl-methyl)-carbamoyl]-5-methyl-2-methylene-hexanoic acid (188729-01-3) → KBR 7785

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / 10 percent Pd/C / methanol / Ambient temperature

2: HOBT*H₂O, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, Et₃N / dimethylformamide / 12 h / Ambient temperature

3: 50 percent / H₂ / 10 percent Pd/C / methanol; tetrahydrofuran / Ambient temperature

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm970404a

upstream raw materials:

formaldehyd

2-{(R)-1-[((S)-Cyclohexyl-methylcarbamoyl-methyl)-carbamoyl]-3-methyl-butyl}-malonic acid dibenzyl ester

Downstream raw materials:

(R)-3-[((S)-Cyclohexyl-methylcarbamoyl-methyl)-carbamoyl]-2,5-dimethyl-hexanoic acid

N⁴-benzyloxy-N¹-(cyclohexyl-methylcarbamoyl-methyl)-2-isobutyl-3-methyl-succinamide