Technology Process of (E)-3-oxo-5α-cholest-7,25-enoic acid
There total 1 articles about (E)-3-oxo-5α-cholest-7,25-enoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 20 °C
1.2: 0 °C
2.1: 2-iodoxybenzoic acid; trifluoroacetic acid / dimethyl sulfoxide / 60 °C / Darkness
3.1: lithium; ammonia / tert-butyl alcohol; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
4.1: N-ethyl-N,N-diisopropylamine; lithium chloride / acetonitrile / 0.25 h / 20 °C
4.2: 20 °C
5.1: Burgess Reagent / toluene / Reflux
6.1: lithium hydroxide / methanol; tetrahydrofuran; water / 20 °C
With
Burgess Reagent; 2-iodoxybenzoic acid; ammonia; lithium; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium chloride; lithium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; toluene; acetonitrile; tert-butyl alcohol;
5.1: |Burgess Alcohol Dehydration;
DOI:10.1002/anie.201307465
- Guidance literature:
-
(E)-3-oxo-5α-cholest-7,25-enoic acid;
In
methanol;
for 0.25h;
Inert atmosphere;
With
Ru(OCOCH3)2{(S)-2,2'-bis(diphenylphosphino)-1,1'-dinaphthyl)}; hydrogen;
In
methanol;
at 50 ℃;
for 3.01667h;
diastereoselective reaction;
DOI:10.1002/anie.201307465
- Guidance literature:
-
(E)-3-oxo-5α-cholest-7,25-enoic acid;
In
methanol;
for 0.25h;
Inert atmosphere;
Schlenk technique;
With
bis(acetato){(R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl}rutenium(II); hydrogen;
In
methanol;
at 50 ℃;
for 3.01667h;
diastereoselective reaction;
DOI:10.1002/anie.201307465
