(5R)-5-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-3-(6-{[4-(3-{[1-(2-propen-1-yl)-3-buten-1-yl]sulfonyl}phenyl)butyl]oxy}hexyl)-1,3-oxazolidin-2-one

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Chemical Name:(5R)-5-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-3-(6-{[4-(3-{[1-(2-propen-1-yl)-3-buten-1-yl]sulfonyl}phenyl)butyl]oxy}hexyl)-1,3-oxazolidin-2-one
CAS No.:686351-13-3
Molecular Formula:C₃₆H₄₉NO₇S
Molecular Weight:639.854
Hs Code.:

Synonyms:(5R)-5-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-3-(6-{[4-(3-{[1-(2-propen-1-yl)-3-buten-1-yl]sulfonyl}phenyl)butyl]oxy}hexyl)-1,3-oxazolidin-2-one

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Chemical Property of (5R)-5-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-3-(6-{[4-(3-{[1-(2-propen-1-yl)-3-buten-1-yl]sulfonyl}phenyl)butyl]oxy}hexyl)-1,3-oxazolidin-2-one

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Technology Process of (5R)-5-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-3-(6-{[4-(3-{[1-(2-propen-1-yl)-3-buten-1-yl]sulfonyl}phenyl)butyl]oxy}hexyl)-1,3-oxazolidin-2-one

There total 5 articles about (5R)-5-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-3-(6-{[4-(3-{[1-(2-propen-1-yl)-3-buten-1-yl]sulfonyl}phenyl)butyl]oxy}hexyl)-1,3-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 686351-11-1
1-[(1-allylbut-3-enyl)sulfonyl]-3-bromobenzene

: 686351-12-2
(5R)-3-[6-(3-buten-1-yloxy)hexyl]-5-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one

: 686351-13-3
(5R)-5-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-3-(6-{[4-(3-{[1-(2-propen-1-yl)-3-buten-1-yl]sulfonyl}phenyl)butyl]oxy}hexyl)-1,3-oxazolidin-2-one

Guidance literature:: (5R)-3-[6-(3-buten-1-yloxy)hexyl]-5-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one; With 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

1-[(1-allylbut-3-enyl)sulfonyl]-3-bromobenzene; With potassium phosphate; palladium diacetate; triphenylphosphine; In tetrahydrofuran; water; at 60 ℃; for 22h; Inert atmosphere;
DOI:10.1021/jm401532g

Reference yield:

: 452339-73-0
(5R)-5-(2,2-dimethyl- 4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one

: 686351-13-3
(5R)-5-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-3-(6-{[4-(3-{[1-(2-propen-1-yl)-3-buten-1-yl]sulfonyl}phenyl)butyl]oxy}hexyl)-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C / Inert atmosphere

1.2: 3 h / Inert atmosphere

2.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2.2: 22 h / 60 °C / Inert atmosphere

With sodium hydride; 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; 2.2: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm401532g

Reference yield:

: 629-03-8
1 ,6-dibromohexane

: 686351-13-3
(5R)-5-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-3-(6-{[4-(3-{[1-(2-propen-1-yl)-3-buten-1-yl]sulfonyl}phenyl)butyl]oxy}hexyl)-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; tetrabutylammomium bromide / 18 h / 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C / Inert atmosphere

2.2: 3 h / Inert atmosphere

3.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

3.2: 22 h / 60 °C / Inert atmosphere

With tetrabutylammomium bromide; sodium hydride; 9-bora-bicyclo[3.3.1]nonane; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; 3.2: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm401532g