(S)-1-(((R)-1-amino-5-(benzyloxy)-1,5-dioxopentan-2-yl)amino)-1-oxopropan-2-aminium 2,2,2-trifluoroacetate

Base Information

Chemical Name:(S)-1-(((R)-1-amino-5-(benzyloxy)-1,5-dioxopentan-2-yl)amino)-1-oxopropan-2-aminium 2,2,2-trifluoroacetate
CAS No.:66025-93-2
Molecular Formula:C₂HF₃O₂*C₁₅H₂₁N₃O₄
Molecular Weight:421.373
Hs Code.:

Synonyms:(S)-1-(((R)-1-amino-5-(benzyloxy)-1,5-dioxopentan-2-yl)amino)-1-oxopropan-2-aminium 2,2,2-trifluoroacetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-(((R)-1-amino-5-(benzyloxy)-1,5-dioxopentan-2-yl)amino)-1-oxopropan-2-aminium 2,2,2-trifluoroacetate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-1-(((R)-1-amino-5-(benzyloxy)-1,5-dioxopentan-2-yl)amino)-1-oxopropan-2-aminium 2,2,2-trifluoroacetate

There total 13 articles about (S)-1-(((R)-1-amino-5-(benzyloxy)-1,5-dioxopentan-2-yl)amino)-1-oxopropan-2-aminium 2,2,2-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 18814-49-8
Boc-L-alanyl-D-isoglutamine benzyl ester

: 76-05-1
trifluoroacetic acid

: 66025-93-2
L-alanyl-D-isoglutamine benzyl ester trifluoroacetate

Guidance literature:: for 0.25h; Ambient temperature;

Reference yield:

: 18800-73-2,19238-66-5
benzyl (R)-5-amino-4-((tert-butoxycarbonyl)amino)-5-oxopentanoate

: 66025-93-2
(S)-1-(((R)-1-amino-5-(benzyloxy)-1,5-dioxopentan-2-yl)amino)-1-oxopropan-2-aminium 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 4 h / 20 °C / Inert atmosphere

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole; 2,2,6,6-tetramethyl-piperidine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere

3: dichloromethane / 1 h / 20 °C / Inert atmosphere

With 2,2,6,6-tetramethyl-piperidine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1021/acs.jmedchem.6b00681

Reference yield:

: 80143-17-5
(R)-1-amino-5-(benzyloxy)-1,5-dioxopentan-2-aminium 2,2,2-trifluoroacetate

: 66025-93-2
(S)-1-(((R)-1-amino-5-(benzyloxy)-1,5-dioxopentan-2-yl)amino)-1-oxopropan-2-aminium 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole; 2,2,6,6-tetramethyl-piperidine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere

2: dichloromethane / 1 h / 20 °C / Inert atmosphere

With 2,2,6,6-tetramethyl-piperidine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1021/acs.jmedchem.6b00681