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18814-49-8

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18814-49-8 Usage

General Description

BOC-ALA-D-GLU(OBZL)-NH2 is a scientifically engineered chemical compound often used in the research and pharmaceutical fields. It is largely known for its role in peptide synthesis. The compound is composed of various components - BOC, which is a protecting group for amines, ALA, an abbreviation for Alanine, which is an alpha-amino acid, D-GLU, representing glutamic acid, another alpha-amino acid, but possessing an extra carboxyl group, OBZL, a protecting group used for the side chain of the amino acid, and NH2 indicating the presence of an amino group. This chemical compound thus provides researchers with an elemental basis for creating more complex peptide structures for the purpose of drug discovery and development.

Check Digit Verification of cas no

The CAS Registry Mumber 18814-49-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,8,1 and 4 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 18814-49:
(7*1)+(6*8)+(5*8)+(4*1)+(3*4)+(2*4)+(1*9)=128
128 % 10 = 8
So 18814-49-8 is a valid CAS Registry Number.

18814-49-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name BOC-ALA-D-GLU(OBZL)-NH2

1.2 Other means of identification

Product number -
Other names N-tert-butoxycarbonyl-L-alanyl-D-iso-glutamine benzyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:18814-49-8 SDS

18814-49-8Downstream Products

18814-49-8Relevant articles and documents

Synthesis and spectroscopic characterization of N2-(N-acetyl-6-O-stearoyl-α-D-muramoyl)-L-alanyl-D-isoglutamine

Dick,Jenny

, p. 2951 - 2957 (1993)

-

Synthesis of Carbapenems Containing Peptidoglycan Mimetics and Inhibition of the Cross-Linking Activity of a Transpeptidase of l,d Specificity

Saidjalolov, Saidbakhrom,Edoo, Zainab,Fonvielle, Matthieu,Mayer, Louis,Iannazzo, Laura,Arthur, Michel,Etheve-Quelquejeu, Mélanie,Braud, Emmanuelle

supporting information, p. 3542 - 3551 (2021/02/05)

The carbapenem class of β-lactams has been optimized against Gram-negative bacteria producing extended-spectrum β-lactamases by introducing substituents at position C2. Carbapenems are currently investigated for the treatment of tuberculosis as these drugs are potent covalent inhibitors of l,d-transpeptidases involved in mycobacterial cell wall assembly. The optimization of carbapenems for inactivation of these unusual targets is sought herein by exploiting the nucleophilicity of the C8 hydroxyl group to introduce chemical diversity. As β-lactams are structure analogs of peptidoglycan precursors, the substituents were chosen to increase similarity between the drug and the substrate. Fourteen peptido-carbapenems were efficiently synthesized. They were more effective than the reference drug, meropenem, owing to the positive impact of a phenethylthio substituent introduced at position C2 but the peptidomimetics added at position C8 did not further improve the activity. Thus, position C8 can be modified to modulate the pharmacokinetic properties of highly efficient carbapenems.

NOVEL MURAMYL PEPTIDE DERIVATIVE COMPOUND, SYNTHESIS AND USES THEREOF

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Paragraph 0163; 0171, (2019/01/04)

The invention relates to novel Muramyl Dipeptide (MDP) derivative compound of structural Formula-VIII, a process for synthesis, intermediates used in the synthesis and use thereof; wherein R1 and R2 both are hydrogen; or R1 is hydrogen and R2 is alkyl or aryl; or R1 is alkyl or aryl and R2 is hydrogen; or R1 and R2 both are alkyl or aryl (same or different groups); wherein alkyl group constitute C1-C6 alkyl or higher (both linear and branched) with or without heteroatoms; and aryl group constitute phenyl, substituted phenyl, heteraryl, arylalkyl and polynuclear aromatics. These compounds possess excellent pharmacological properties, in particular immunomodulating properties for use as adjuvant in vaccine formulations. These compounds are, particularly useful as adjuvants in vaccines.

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