N-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide

Base Information

Chemical Name:N-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide
CAS No.:1361330-08-6
Molecular Formula:C₂₅H₂₄F₂N₄O₄S
Molecular Weight:514.553
Hs Code.:

Synonyms:N-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide

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Chemical Property of N-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide

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Technology Process of N-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide

There total 4 articles about N-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1361330-35-9
N-[1-{[3-(aminomethyl)phenyl]methyl}-4-(methyloxy)-1H-indazol-3-yl]-3-fluoro-4-methylbenzenesulfonamide

: 64-19-7,77671-22-8
acetic acid

: 1361330-08-6
N-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide

Guidance literature:: acetic acid; With HATU; In N,N-dimethyl-formamide; for 0.05h; Inert atmosphere;

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.05h;

N-[1-{[3-(aminomethyl)phenyl]methyl}-4-(methyloxy)-1H-indazol-3-yl]-3-fluoro-4-methylbenzenesulfonamide; In N,N-dimethyl-formamide; for 3h;

Reference yield:

: 1240518-02-8
3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}-benzonitrile

: 1361330-08-6
N-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 21 h / 21 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 2 h / 0 °C

3.1: HATU / N,N-dimethyl-formamide / 0.05 h / Inert atmosphere

3.2: 0.05 h

3.3: 3 h

With pyridine; lithium aluminium tetrahydride; HATU; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;

Reference yield:

: 886362-07-8
4-(methyloxy)-1H-indazol-3-amine

: 1361330-08-6
N-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 0.33 h / 20 °C / Inert atmosphere

2.1: pyridine / 21 h / 21 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 2 h / 0 °C

4.1: HATU / N,N-dimethyl-formamide / 0.05 h / Inert atmosphere

4.2: 0.05 h

4.3: 3 h

With pyridine; lithium aluminium tetrahydride; HATU; potassium hydroxide; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide;