4-tert-butyl-N-[2-cyclopropyl-6-(2-hydroxy-ethoxy)-5-(2-methoxyphenoxy)-pyrimidin-4-yl]-benzenesulfonamide

Base Information

• Chemical Name: 4-tert-butyl-N-[2-cyclopropyl-6-(2-hydroxy-ethoxy)-5-(2-methoxyphenoxy)-pyrimidin-4-yl]-benzenesulfonamide
• CAS No.: 150726-47-9
• Molecular Formula: C₂₆H₃₁N₃O₆S
• Molecular Weight: 513.615

Synonyms:4-tert-butyl-N-[2-cyclopropyl-6-(2-hydroxy-ethoxy)-5-(2-methoxyphenoxy)-pyrimidin-4-yl]-benzenesulfonamide

Chemical Property of 4-tert-butyl-N-[2-cyclopropyl-6-(2-hydroxy-ethoxy)-5-(2-methoxyphenoxy)-pyrimidin-4-yl]-benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-tert-butyl-N-[2-cyclopropyl-6-(2-hydroxy-ethoxy)-5-(2-methoxyphenoxy)-pyrimidin-4-yl]-benzenesulfonamide

There total 3 articles about 4-tert-butyl-N-[2-cyclopropyl-6-(2-hydroxy-ethoxy)-5-(2-methoxyphenoxy)-pyrimidin-4-yl]-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-tert-butyl-N-[6-chloro-2-cyclopropyl-5-(2-methoxy-phenoxy)-pyrimidin-4-yl]-benzenesulfonamide (150727-73-4) → 4-tert-butyl-N-[2-cyclopropyl-6-(2-hydroxy-ethoxy)-5-(2-methoxyphenoxy)-pyrimidin-4-yl]-benzenesulfonamide (150726-47-9)

Guidance literature:

In ethylene glycol;

Reference yield:

rac-2-cyclopropyl-5-(2-methoxy-phenoxy)-1H-pyrimidine-4,6-dione (150727-02-9) → 4-tert-butyl-N-[2-cyclopropyl-6-(2-hydroxy-ethoxy)-5-(2-methoxyphenoxy)-pyrimidin-4-yl]-benzenesulfonamide (150726-47-9)

Guidance literature:

Multi-step reaction with 2 steps

1: POCl₃, PCl₅ / Heating

2: 2.) Na / 1.) DMSO, rt, 2.) 100 deg C

With phosphorus pentachloride; sodium; trichlorophosphate;

DOI:10.1016/S0960-894X(97)00400-9

Reference yield:

ethylene glycol (107-21-1) + 4,6-dichloro-5-(2-methoxyphenoxy)-2-cyclopropyl-pyrimidine (329924-27-8) + potassium 4-tert-butylbenzenesulfonate → 4-tert-butyl-N-[2-cyclopropyl-6-(2-hydroxy-ethoxy)-5-(2-methoxyphenoxy)-pyrimidin-4-yl]-benzenesulfonamide (150726-47-9)

Guidance literature:

With sodium; Multistep reaction; 1.) DMSO, rt, 2.) 100 deg C;

DOI:10.1016/S0960-894X(97)00400-9

upstream raw materials:

ethylene glycol

4,6-dichloro-5-(2-methoxyphenoxy)-2-cyclopropyl-pyrimidine

rac-2-cyclopropyl-5-(2-methoxy-phenoxy)-1H-pyrimidine-4,6-dione

4-tert-butyl-N-[6-chloro-2-cyclopropyl-5-(2-methoxy-phenoxy)-pyrimidin-4-yl]-benzenesulfonamide

Downstream raw materials:

pyridin-2-ylcarbamic acid 2-[6-(4-tert-butyl-phenylsulfonylamino)-2-cyclopropyl-5-(2-methoxy-phenoxy)-pyrimidin-4-yloxy]-ethyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 150726-47-9 4-tert-butyl-N-[2-cyclopropyl-6-(2-hydroxy-ethoxy)-5-(2-methoxyphenoxy)-pyrimidin-4-yl]-benzenesulfonamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send