(1'S,2'S,3'R)-1-[2',3'-bis(benzoyloxymethyl)cyclobutyl]-N⁴-benzoylcytosine

Base Information

Chemical Name:(1'S,2'S,3'R)-1-[2',3'-bis(benzoyloxymethyl)cyclobutyl]-N⁴-benzoylcytosine
CAS No.:283598-01-6
Molecular Formula:C₃₁H₂₇N₃O₆
Molecular Weight:537.572
Hs Code.:

(1'S,2'S,3'R)-1-[2',3'-bis(benzoyloxymethyl)cyclobutyl]-N<sup>4</sup>-benzoylcytosine

Synonyms:(1'S,2'S,3'R)-1-[2',3'-bis(benzoyloxymethyl)cyclobutyl]-N⁴-benzoylcytosine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1'S,2'S,3'R)-1-[2',3'-bis(benzoyloxymethyl)cyclobutyl]-N⁴-benzoylcytosine

Chemical Property:

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Technology Process of (1'S,2'S,3'R)-1-[2',3'-bis(benzoyloxymethyl)cyclobutyl]-N⁴-benzoylcytosine

There total 1 articles about (1'S,2'S,3'R)-1-[2',3'-bis(benzoyloxymethyl)cyclobutyl]-N⁴-benzoylcytosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 132294-26-9
<1R-(1α,2β,3β)>-3-<<(4-methylphenyl)sulfonyl>oxy>-1,2-cyclobutanedimethanol dibenzoate ester

: 100-44-7
benzyl chloride

: 66-22-8,144104-68-7,18324-22-6,27072-01-1,2920-92-5,51953-19-6
uracil

: 283598-01-6
(1'S,2'S,3'R)-1-[2',3'-bis(benzoyloxymethyl)cyclobutyl]-N⁴-benzoylcytosine

Guidance literature:: Multistep reaction;
DOI:10.1016/S0040-4020(00)00162-9

Reference yield: 86.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 283598-01-6
(1'S,2'S,3'R)-1-[2',3'-bis(benzoyloxymethyl)cyclobutyl]-N⁴-benzoylcytosine

: 283598-06-1
(1'S,2'S,3'R)-1-{2',3'-bis[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}cytosine

Guidance literature:: (1'S,2'S,3'R)-1-[2',3'-bis(benzoyloxymethyl)cyclobutyl]-N⁴-benzoylcytosine; With triethylamine; In methanol; water; at 20 ℃; for 12h;

4,4'-dimethoxytrityl chloride; With pyridine; at 20 ℃; for 12h;
DOI:10.1016/S0040-4020(00)00162-9

Reference yield:

: 283598-01-6
(1'S,2'S,3'R)-1-[2',3'-bis(benzoyloxymethyl)cyclobutyl]-N⁴-benzoylcytosine

: 4-Amino-1-{(1S,2S,3R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxymethyl-cyclobutyl}-1H-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: Et₃N / H₂O; methanol / 12 h / 20 °C

1.2: 86 percent / Py / 12 h / 20 °C

2.1: 10 percent / AcOH / methanol; CHCl₃ / 3 h / 20 °C

With acetic acid; triethylamine; In methanol; chloroform; water; 1.1: Hydrolysis / 1.2: Substitution / 2.1: Substitution;
DOI:10.1016/S0040-4020(00)00162-9