(4Z,7Z)-3-(tert-butyldimethylsilyloxy)-8-chloro-10-((2R,4R,5R)-4-hydroxy-5-((4-methoxybenzyloxy)methyl)tetrahydrofuran-2-yl)-4-methyldeca-4,7-dienoic acid

Base Information

Chemical Name:(4Z,7Z)-3-(tert-butyldimethylsilyloxy)-8-chloro-10-((2R,4R,5R)-4-hydroxy-5-((4-methoxybenzyloxy)methyl)tetrahydrofuran-2-yl)-4-methyldeca-4,7-dienoic acid
CAS No.:1041437-00-6
Molecular Formula:C₃₀H₄₇ClO₇Si
Molecular Weight:583.237
Hs Code.:

(4Z,7Z)-3-(tert-butyldimethylsilyloxy)-8-chloro-10-((2R,4R,5R)-4-hydroxy-5-((4-methoxybenzyloxy)methyl)tetrahydrofuran-2-yl)-4-methyldeca-4,7-dienoic acid

Synonyms:(4Z,7Z)-3-(tert-butyldimethylsilyloxy)-8-chloro-10-((2R,4R,5R)-4-hydroxy-5-((4-methoxybenzyloxy)methyl)tetrahydrofuran-2-yl)-4-methyldeca-4,7-dienoic acid

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Chemical Property of (4Z,7Z)-3-(tert-butyldimethylsilyloxy)-8-chloro-10-((2R,4R,5R)-4-hydroxy-5-((4-methoxybenzyloxy)methyl)tetrahydrofuran-2-yl)-4-methyldeca-4,7-dienoic acid

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Technology Process of (4Z,7Z)-3-(tert-butyldimethylsilyloxy)-8-chloro-10-((2R,4R,5R)-4-hydroxy-5-((4-methoxybenzyloxy)methyl)tetrahydrofuran-2-yl)-4-methyldeca-4,7-dienoic acid

There total 1 articles about (4Z,7Z)-3-(tert-butyldimethylsilyloxy)-8-chloro-10-((2R,4R,5R)-4-hydroxy-5-((4-methoxybenzyloxy)methyl)tetrahydrofuran-2-yl)-4-methyldeca-4,7-dienoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1041436-98-9
(2R,3R,5R)-5-((3Z,6Z)-8-(tert-butyldimethylsilyloxy)-3-chloro-10-ethoxy-7-methyl-10-oxodeca-3,6-dienyl)-2-((4-methoxybenzyloxy)methyl)tetrahydrofuran-3-yl benzoate

: 1041437-00-6
(4Z,7Z)-3-(tert-butyldimethylsilyloxy)-8-chloro-10-((2R,4R,5R)-4-hydroxy-5-((4-methoxybenzyloxy)methyl)tetrahydrofuran-2-yl)-4-methyldeca-4,7-dienoic acid

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; methanol; water; at 0 - 20 ℃; for 6.5h;
DOI:10.1002/anie.200800585

Reference yield: 55.0%

: 1041437-00-6
(4Z,7Z)-3-(tert-butyldimethylsilyloxy)-8-chloro-10-((2R,4R,5R)-4-hydroxy-5-((4-methoxybenzyloxy)methyl)tetrahydrofuran-2-yl)-4-methyldeca-4,7-dienoic acid

: 1041437-13-1
(1R,6Z,9Z,13R,15R)-5-(tert-butyldimethylsilyloxy)-10-chloro-15-((4-methoxybenzyloxy)methyl)-6-methyl-2,14-dioxabicyclo[11.2.1]hexadeca-6,9-dien-3-one

Guidance literature:: (4Z,7Z)-3-(tert-butyldimethylsilyloxy)-8-chloro-10-((2R,4R,5R)-4-hydroxy-5-((4-methoxybenzyloxy)methyl)tetrahydrofuran-2-yl)-4-methyldeca-4,7-dienoic acid; With 2,4,6-trichlorobenzoyl chloride; triethylamine; In tetrahydrofuran; for 2.5h;

With dmap; In tetrahydrofuran; toluene; for 6h; Further stages.;
DOI:10.1002/anie.200800585