1-(3-chloro-5-fluorophenyl)-3-(5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)urea

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Chemical Name:1-(3-chloro-5-fluorophenyl)-3-(5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)urea
CAS No.:1442473-60-0
Molecular Formula:C₂₅H₂₂ClF₂N₅O₂
Molecular Weight:497.932
Hs Code.:

Synonyms:1-(3-chloro-5-fluorophenyl)-3-(5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)urea

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Chemical Property of 1-(3-chloro-5-fluorophenyl)-3-(5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)urea

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Technology Process of 1-(3-chloro-5-fluorophenyl)-3-(5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)urea

There total 13 articles about 1-(3-chloro-5-fluorophenyl)-3-(5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1442473-59-7
1-(3-chloro-5-fluorophenyl)-3-(5-(1-ethyl-7-((4-methoxybenzyl)(methyl)amino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)urea

: 1442473-60-0
1-(3-chloro-5-fluorophenyl)-3-(5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)urea

Guidance literature:: With methoxybenzene; trifluoroacetic acid; at 20 ℃; for 4h;

Reference yield:

: 959162-97-1
6-chloro-4-ethylamino-nicotinic acid ethyl ester

: 1442473-60-0
1-(3-chloro-5-fluorophenyl)-3-(5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)urea

Guidance literature:: Multi-step reaction with 6 steps

1: lithium aluminium tetrahydride / water; tetrahydrofuran / 1 h / -50 - 0 °C

2: manganese(IV) oxide / dichloromethane / 20 °C

3: potassium fluoride; aluminum oxide / N,N-dimethyl acetamide / 2 h / Sonication

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1-methyl-pyrrolidin-2-one / 180 °C / Inert atmosphere

5: sodium hydrogencarbonate / ethyl acetate / 2 h / 20 °C

6: trifluoroacetic acid; methoxybenzene / trifluoroacetic acid / 4 h / 20 °C

With manganese(IV) oxide; aluminum oxide; potassium fluoride; lithium aluminium tetrahydride; sodium hydrogencarbonate; methoxybenzene; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl acetamide; water; ethyl acetate; trifluoroacetic acid;

Reference yield:

: 959162-99-3
(6-chloro-4-(ethylamino)pyridin-3-yl)methanol

: 1442473-60-0
1-(3-chloro-5-fluorophenyl)-3-(5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)urea

Guidance literature:: Multi-step reaction with 5 steps

1: manganese(IV) oxide / dichloromethane / 20 °C

2: potassium fluoride; aluminum oxide / N,N-dimethyl acetamide / 2 h / Sonication

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1-methyl-pyrrolidin-2-one / 180 °C / Inert atmosphere

4: sodium hydrogencarbonate / ethyl acetate / 2 h / 20 °C

5: trifluoroacetic acid; methoxybenzene / trifluoroacetic acid / 4 h / 20 °C

With manganese(IV) oxide; aluminum oxide; potassium fluoride; sodium hydrogencarbonate; methoxybenzene; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; In 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl acetamide; ethyl acetate; trifluoroacetic acid;