2-(3-hydroxy-1-methyl-2-oxoindolin-3-yl)-2-phenylacetonitrile

Base Information

• Chemical Name: 2-(3-hydroxy-1-methyl-2-oxoindolin-3-yl)-2-phenylacetonitrile
• CAS No.: 107155-00-0
• Molecular Formula: C₁₇H₁₄N₂O₂
• Molecular Weight: 278.31
• Mol file: 107155-00-0.mol

Synonyms:2-(3-hydroxy-1-methyl-2-oxoindolin-3-yl)-2-phenylacetonitrile

Chemical Property of 2-(3-hydroxy-1-methyl-2-oxoindolin-3-yl)-2-phenylacetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-hydroxy-1-methyl-2-oxoindolin-3-yl)-2-phenylacetonitrile

There total 3 articles about 2-(3-hydroxy-1-methyl-2-oxoindolin-3-yl)-2-phenylacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

2-(3-hydroxy-2-oxoindolin-3-yl)-2-phenylacetonitrile (101291-04-7) + methyl iodide (74-88-4) → 2-(3-hydroxy-1-methyl-2-oxoindolin-3-yl)-2-phenylacetonitrile (107155-00-0)

Guidance literature:

2-(3-hydroxy-2-oxoindolin-3-yl)-2-phenylacetonitrile; With caesium carbonate; In N,N-dimethyl-formamide; at 0 ℃; for 0.166667h;

methyl iodide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 12h;

DOI:10.1021/acs.joc.7b00512

Reference yield:

2-(3-hydroxy-2-oxo-1-tritylindolin-3-yl)-2-phenylacetonitrile → 2-(3-hydroxy-1-methyl-2-oxoindolin-3-yl)-2-phenylacetonitrile (107155-00-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 12 h / 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 0.17 h / 0 °C

2.2: 12 h / 0 - 20 °C

With caesium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/acs.joc.7b00512

Reference yield:

→ 2-(3-hydroxy-1-methyl-2-oxoindolin-3-yl)-2-phenylacetonitrile (107155-00-0)

Guidance literature:

/BRN= 269375/;

upstream raw materials:

2-(3-hydroxy-2-oxoindolin-3-yl)-2-phenylacetonitrile

methyl iodide