Ethyl 4-<(N-benzoyl-S-methylthiocarbamoyl)amino>-3-(2,3-O-isopropylidene-5-O-trityl-α-D-ribofuranosyl)isothiazole-5-carboxylate

Base Information

Chemical Name:Ethyl 4-<(N-benzoyl-S-methylthiocarbamoyl)amino>-3-(2,3-O-isopropylidene-5-O-trityl-α-D-ribofuranosyl)isothiazole-5-carboxylate
CAS No.:155666-70-9
Molecular Formula:C₄₂H₄₁N₃O₇S₂
Molecular Weight:763.935
Hs Code.:

Synonyms:Ethyl 4-<(N-benzoyl-S-methylthiocarbamoyl)amino>-3-(2,3-O-isopropylidene-5-O-trityl-α-D-ribofuranosyl)isothiazole-5-carboxylate

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Chemical Property of Ethyl 4-<(N-benzoyl-S-methylthiocarbamoyl)amino>-3-(2,3-O-isopropylidene-5-O-trityl-α-D-ribofuranosyl)isothiazole-5-carboxylate

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Technology Process of Ethyl 4-<(N-benzoyl-S-methylthiocarbamoyl)amino>-3-(2,3-O-isopropylidene-5-O-trityl-α-D-ribofuranosyl)isothiazole-5-carboxylate

There total 3 articles about Ethyl 4-<(N-benzoyl-S-methylthiocarbamoyl)amino>-3-(2,3-O-isopropylidene-5-O-trityl-α-D-ribofuranosyl)isothiazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 155666-68-5
Ethyl 4-<(benzoylthiocarbamoyl)amino>-3-(2,3-O-isopropylidene-5-O-trityl-α-D-ribofuranosyl)isothiazole-5-carboxylate

: 74-88-4
methyl iodide

: 155666-70-9
Ethyl 4-<(N-benzoyl-S-methylthiocarbamoyl)amino>-3-(2,3-O-isopropylidene-5-O-trityl-α-D-ribofuranosyl)isothiazole-5-carboxylate

Guidance literature:: With sodium hydride; In dichloromethane; at 25 ℃; for 3h;
DOI:10.1021/jo00086a054

Reference yield:

: 532-55-8
Benzoyl isothiocyanate

: 155666-70-9
Ethyl 4-<(N-benzoyl-S-methylthiocarbamoyl)amino>-3-(2,3-O-isopropylidene-5-O-trityl-α-D-ribofuranosyl)isothiazole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / CH₂Cl₂ / 48 h / 25 °C

2: 91 percent / NaH / CH₂Cl₂ / 3 h / 25 °C

With sodium hydride; In dichloromethane;
DOI:10.1021/jo00086a054

Reference yield:

: 150966-35-1
Ethyl 4-amino-3-(2,3-O-isopropylidene-5-O-trityl-α-D-ribofuranosyl)isothiazole-5-carboxylate

: 155666-70-9
Ethyl 4-<(N-benzoyl-S-methylthiocarbamoyl)amino>-3-(2,3-O-isopropylidene-5-O-trityl-α-D-ribofuranosyl)isothiazole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / CH₂Cl₂ / 48 h / 25 °C

2: 91 percent / NaH / CH₂Cl₂ / 3 h / 25 °C

With sodium hydride; In dichloromethane;
DOI:10.1021/jo00086a054